The serum copeptin levels in obstructive sleep apnea patients with prehypertensive

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dc.authorid0000-0002-3535-5704
dc.authorscopusid26532378600
dc.authorscopusid16315021800
dc.authorscopusid8514414100
dc.authorscopusid54892706700
dc.authorscopusid6505680586
dc.authorscopusid8531050000
dc.authorscopusid36866111300
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorTülübaş, Feti
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorAlp, Recep
dc.date.accessioned2022-05-11T14:07:41Z
dc.date.available2022-05-11T14:07:41Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Copeptin is a precursor of AVP, an antidiuretic hormone, plays a pivotal role in the maintenance of cardiovascular homeostasis. Obstructive sleep apnea syndrome (OSAS) is related to cardiovascular disease. We sought to evaluate the serum copeptin levels in newly diagnosed prehypertensive patients with OSAS. PATIENTS AND METHODS: Eighty-four prehypertensive patients were evaluated using polysomnography and were divided into two groups, an OSAS (n = 41) group and a control (n = 43) group. Serum copeptin levels were measured using the ELISA method. RESULTS: Copeptin levels were significantly higher in the OSAS group compared to the control group (146 [93-739] pg/ml vs. 111 [33-253] pg/ml, respectively, p < 0.001). A regression analysis revealed that the apnea hypopnea index (AHI) and the lowest SpO(2) were related to serum copeptin levels (unstandardized beta = 1.02 +/- 0.40, p = 0.014 and unstandardized beta = -3.1 +/- 0.9, p = 0.048 respectively). CONCLUSIONS: According to the results of our study, serum copeptin levels are higher in the prehypertensive patients with OSAS compared to those in the control group. Therefore, in assessing the severity of OSAS, serum copeptin levels can be a candidate for a biochemical marker in addition to polysomnographic findings.
dc.identifier.endpage1728
dc.identifier.issn1128-3602
dc.identifier.issue9en_US
dc.identifier.pmid26004616
dc.identifier.scopus2-s2.0-84942274912
dc.identifier.scopusqualityQ2
dc.identifier.startpage1721
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5177
dc.identifier.volume19
dc.identifier.wosWOS:000355744400028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkkoyun, Dursun Ceyhan
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorTülübaş, Feti
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorAlp, Recep
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrehypertension
dc.subjectObstructive sleep apnea
dc.subjectCopeptin
dc.subjectVasopressin
dc.subjectCardiac diseases
dc.subjectPositive Airway Pressure
dc.subjectC-Reactive Protein
dc.subjectMyocardial-Infarction
dc.subjectEuropean-Association
dc.subjectManagement
dc.subjectGuidelines
dc.subjectPrecursor
dc.subjectBiomarker
dc.subjectCommittee
dc.titleThe serum copeptin levels in obstructive sleep apnea patients with prehypertensive
dc.typeArticle

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