Characterization of the apelin-1860T>C polymorphism in Turkish coronary artery disease patients and healthy individuals

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dc.authorscopusid35764299300
dc.authorscopusid23391660500
dc.authorscopusid56895970700
dc.authorscopusid57000520600
dc.authorscopusid56503950500
dc.authorscopusid47561138500
dc.authorscopusid57000551800
dc.contributor.authorAkçılar, Raziye
dc.contributor.authorYümün, Gündüz
dc.contributor.authorBayat, Zeynep
dc.contributor.authorDonbaloğlu, Mehmet Okan
dc.contributor.authorErselcan, Kubilay
dc.contributor.authorEce, Ezgi
dc.contributor.authorGenç, Osman
dc.date.accessioned2022-05-11T14:35:59Z
dc.date.available2022-05-11T14:35:59Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractTo evaluate the association between the apelin -1860T>C polymorphism and plasma apelin levels in Turkish patients with coronary artery disease (CAD). A total of 276 individuals were enrolled in the present study, including 158 patients with CAD and 118 individuals without CAD as controls. The presence of the apelin -1860T>C gene polymorphism and plasma apelin levels were determined using polymerase chain reaction/restriction fragment length polymorphism and enzyme-linked immunosorbent assay, respectively. Significance was set at p?0.05 for all statistical analyses. The genotype and allele frequencies of interested genes were significantly different between groups (?2=10.2; df=2; p=0.006 and ?2=13.4; df=1; p=0.000, respectively). Frequency of CC genotype and the C allele of -1860T>C site was significantly higher in CAD patients compared to healthy controls. We found that individuals with the TC and CC genotypes were associated with an increased risk of CAD when compared with the TT genotype in CAD patients, and the adjusted ORs (95% CI) were 6.50 (1.27-33.0) and 6.39 (1.77-23.0), respectively. Plasma apelin levels were significantly lower in CAD patients compared to control group. Apelin level of CAD patient group having CC genotype of -1860T>C site was significantly lower compared to those having TT genotypes, but it was not statistically significant (p > 0.05). The homozygous CC genotype of apelin gene is associated with high risk of CAD. Apelin gene polymorphism -1860T>C is a significant predictor of predisposition to CAD in in Turkish population. © 2015, E-Century Publishing Corporation. All rights reserved.
dc.identifier.endpage171
dc.identifier.issn1944-8171
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84960385007
dc.identifier.scopusqualityN/A
dc.identifier.startpage165
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8322
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.institutionauthorYümün, Gündüz
dc.institutionauthorDonbaloğlu, Mehmet Okan
dc.language.isoen
dc.publisherE-Century Publishing Corporation
dc.relation.ispartofInternational Journal of Physiology, Pathophysiology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApelin-1860T>C gene
dc.subjectCoronary artery disease
dc.subjectPolymorphism
dc.subjectapelin receptor
dc.subjectadult
dc.subjectangiography
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectblood analysis
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectdisease predisposition
dc.subjectDNA polymorphism
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic analysis
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.titleCharacterization of the apelin-1860T>C polymorphism in Turkish coronary artery disease patients and healthy individuals
dc.typeArticle

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