The effects of caffeic acid phenethyl ester (CAPE) on bacterial translocation and inflammatory response in an experimental intestinal obstruction model in rats

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dc.authorscopusid6503901620
dc.authorscopusid15840512200
dc.authorscopusid17134802600
dc.authorscopusid22957986500
dc.authorscopusid36876924700
dc.authorscopusid36599200500
dc.authorscopusid36503912900
dc.authorwosidSENOL, SERKAN/C-9858-2018
dc.authorwosidEvliyaoglu, Osman/AAR-1055-2021
dc.authorwosidEVLİYAOĞLU, OSMAN/AAJ-1225-2020
dc.contributor.authorFırat, U.
dc.contributor.authorSenol, S.
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorKapan, M.
dc.contributor.authorTokgöz, O.
dc.contributor.authorTekin, R.
dc.contributor.authorAlp, H.
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Intestinal obstruction (IO) is a disease which generates approximately 20% of emergency surgery and tends to with high mortality. Prevention of oxidative stress, bacterial translocation and tissue damage caused by IO is an important medical issue. Caffeic acid phenethyl ester (CAPE) is an anti-inflammatory, antioxidant, anti-bacterial and immunomodulatory agent. In this experimental study, we aimed to investigate the effects of CAPE on bacterial translocation, inflammatory response, oxidative stress and tissue injury caused by intestinal obstruction in a rat model. MATERIALS AND METHODS: Breafly, thirty Wistar albino rats divided into three groups as Sham (n=10), IO (n=10) and IO + CAPE (10 mu mol/kg day, intraperitoneal) (n=10). The tissues from the study groups were examined biochemically, microbiologically and histopathologically. RESULTS: In CAPE treated group, decreased serum levels of proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta) and CRP (p < 0.05), additionally increased serum levels of antioxidant parameters (PONS, TAS) (p < 0.05), were observed after IO. Microbiologically, the rates of positive cultures of the lymph node, spleen, liver and blood were significantly decreased in CAPE treated group compared to the IO group. Also histopathological examination showed that the intestinal mucosal injury score and hepatic portal inflammation score were significantly decreased in the CAPE treated group (p < 0.05). CONCLUSIONS: It is suggested that intraperitoneal administration of CAPE might has potential antibacterial, anti-inflammatory, antioxidant and immunomodulatory effects in IO. So, further studies on IO are needed to evaluate exact antibacterial, antiinflammatory, antioxidant and immunomodulatory effects of CAPE.
dc.identifier.endpage1914
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid26044239
dc.identifier.scopus2-s2.0-84942082117
dc.identifier.scopusqualityQ2
dc.identifier.startpage1907
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8479
dc.identifier.volume19
dc.identifier.wosWOS:000355811500027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGelincik, İbrahim
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIntestinal obstruction
dc.subjectCAPE
dc.subjectBacterial translocation
dc.subjectInflammatory response
dc.subjectC-Reactive Protein
dc.subjectIschemia/Reperfusion Injury
dc.subjectGastrointestinal-Tract
dc.subjectReperfusion Injury
dc.subjectAntibacterial
dc.subjectPropolis
dc.subjectIschemia
dc.subjectRabbits
dc.titleThe effects of caffeic acid phenethyl ester (CAPE) on bacterial translocation and inflammatory response in an experimental intestinal obstruction model in rats
dc.typeArticle

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