Aortic ischemia-reperfusion injury and potency of fluoxetine

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dc.authoridYaman, Onur Muhittin/0000-0003-3561-3977
dc.authorwosidYaman, Onur Muhittin/H-7628-2014
dc.contributor.authorAltan, Mehmet
dc.contributor.authorYaman, Muhittin Onur
dc.contributor.authorKervancıoğlu, Gülnaz
dc.contributor.authorKılıç, Aysu
dc.contributor.authorDemirci, Elif Kervancıoğlu
dc.contributor.authorPolat, Sila Hidayet Bozdoğan
dc.contributor.authorKaradeniz, Zeliha
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective(s): Due to cross-clamping of the aorta during aortic aneurysm surgeries, ischemia-reperfusion (IR) develops, and it may cause damage to the aorta itself or even to remote organs by oxidative stress or inflammation. Fluoxetine (FLX) which might be used in the preoperative period for its tranquilizing effect also has antioxidant effects in short-term use. The purpose of our study is to examine whether FLX protects aorta tissue, against the damage caused by IR. Materials and Methods: Three groups of Wistar rats were formed randomly. 1) Control group (sham -operated), 2) IR group (60 min ischemia+120 min perfusion), and 3) FLX+IR group (FLX dose was 20 mg/kg for 3 days IP before IR). At the end of each procedure, aorta samples were collected, and oxidant-antioxidant, anti-inflammatory, and anti-apoptotic status of the aorta were evaluated. Histological examinations of the samples were provided. Results: Levels of LOOH, MDA, ROS, TOS, MPO, TNF alpha, IL-1 beta, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA were found to be significantly increased in the IR group compared with control (P<0.05) and SOD, GSH, TAS, and IL-10 levels were significantly lower (P<0.05). FLX significantly decreased LOOH, MDA, ROS, TOS, MPO, TNF alpha, IL-1 beta, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA levels in the FLX+IR group compared with IR group (P<0.05) and increased IL-10, SOD, GSH, and TAS (P<0.05). FLX administration prevented the deterioration of aortic tissue damage. Conclusion: Our study is the first study that demonstrates FLX-mediated suppression of IR injury in the infrarenal abdominal aorta by antioxidant, anti-inflammatory, and anti-apoptotic properties.
dc.identifier.doi10.22038/IJBMS.2023.65974.14508
dc.identifier.endpage307
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85148300952
dc.identifier.scopusqualityQ2
dc.identifier.startpage301
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2023.65974.14508
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12176
dc.identifier.volume26
dc.identifier.wosWOS:000926195700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGüner, İbrahim
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal Of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAorta
dc.subjectApoptosis
dc.subjectFluoxetine
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectRats
dc.subjectReperfusion injury
dc.subjectSurgery
dc.subjectActivation
dc.subjectExpression
dc.titleAortic ischemia-reperfusion injury and potency of fluoxetine
dc.typeArticle

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