A rare cause of fever in an adult: a case of familial Mediterranean fever

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dc.authorid0000-0003-2440-7529
dc.authorscopusid6602163658
dc.authorscopusid56568272400
dc.authorscopusid57203430154
dc.authorscopusid57202750841
dc.authorscopusid57201252046
dc.authorscopusid57190404723
dc.authorscopusid57202741493
dc.authorwosidKARAALİ, Rıdvan/AAQ-1018-2020
dc.contributor.authorErdem, İlknur
dc.contributor.authorSaritas, Fatih
dc.contributor.authorKaraali, Rıdvan
dc.contributor.authorArdic, Enes
dc.contributor.authorEmeksiz, Gaye Kübra
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorBol, Oguzhan
dc.date.accessioned2022-05-11T14:12:33Z
dc.date.available2022-05-11T14:12:33Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground: Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent fever attacks and serositis. Nonspecific manifestations of the FMF can mimic many common acquired disorders such as infections and acute abdomen. This can delay recognition for many years and lead to comprehensive assessments and even unnecessary surgeries. Untreated FMF may lead to serious complications such as end-stage renal disease and malabsorption due to amyloid deposits in the kidneys and the digestive system. Colchicine has been used successfully to treat FMF since the 1970s. Case presentation: A 30-year-old male was admitted to our hospital with the complaints of fever, nausea, vomiting, and generalized myalgia and weakness for 15 days. The day after hospitalization, the patient had abdominal pain. Approximately a month before, the patient was treated for a diagnosis of urinary tract infection, with similar complaints. MEFV gene mutation analysis revealed homozygosity for the R202Q mutation. FMF was considered in the patient due to the presence of recurrent febrile serositis attacks and R202Q homozygous mutation in the FMF gene analyses. Colchicine was started 3x0.5 mg/day by consulting rheumatology on day 8 of admission. After the colchicine treatment, the patient's complaints markedly improved and the inflammatory markers returned to normal levels. At his follow-up visit at 6 months, the patient remained asymptomatic. Conclusion: We present a case of adult-onset FMF accompanied by peritonitis as a disease among the rare causes of fever in an adult who was treated with colchicine. Based on this case, we suggest that FMF should be kept in mind in the differential diagnosis of patients with periodic fever syndromes.
dc.identifier.doi10.2147/IMCRJ.S148205
dc.identifier.endpage40
dc.identifier.issn1179-142X
dc.identifier.pmid29559814
dc.identifier.scopus2-s2.0-85049162647
dc.identifier.scopusqualityQ3
dc.identifier.startpage37
dc.identifier.urihttps://doi.org/10.2147/IMCRJ.S148205
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5595
dc.identifier.volume11
dc.identifier.wosWOS:000427426200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, İlknur
dc.institutionauthorKaraali, Rıdvan
dc.institutionauthorArdic, Enes
dc.institutionauthorEmeksiz, Gaye Kübra
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorBol, Oguzhan
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Medical Case Reports Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfamilial Mediterranean fever
dc.subjectfever
dc.subjectperitonitis
dc.subjectSubclinical Inflammation
dc.subjectColchicine
dc.subjectMutations
dc.subjectDiagnosis
dc.titleA rare cause of fever in an adult: a case of familial Mediterranean fever
dc.typeArticle

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