Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis

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dc.authoridTerzi, Menderes Yusuf/0000-0001-8478-0451
dc.authoridOKUYAN, HAMZA MALIK/0000-0001-7616-3330
dc.authorscopusid55963510600
dc.authorscopusid56047982200
dc.authorscopusid55838809000
dc.authorscopusid57836358300
dc.authorscopusid57208693564
dc.authorscopusid8855265500
dc.authorwosidTerzi, Menderes Yusuf/Z-1999-2018
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorGökdemir, Cemil Emre
dc.contributor.authorTap, Duygu
dc.contributor.authorKalaci, Aydiner
dc.date.accessioned2023-04-20T08:04:11Z
dc.date.available2023-04-20T08:04:11Z
dc.date.issued2022
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractOsteoarthritis (OA) is a common degenerative articular disorder caused by traumatic or spontaneous factors such as genetics, obesity, and advanced age. Comprehending the pathogenic mechanism of OA ensures the development of novel disease-modifying therapeutics rather than conventional palliative drugs with undesired side effects. Urotensin-II (UII) is a multifunctional short cyclic peptide implicated in several disorders. We aimed to analyze the effects of intraarticular UII treatment in a monosodium iodoacetate (MIA)-induced OA rat model. We divided animals into six groups to test three different concentrations of UII with histopathological and immunohistochemical analyses of bone morphogenetic protein-2 (BMP-2), nuclear factor kappa B subunit 1 (NF-kappa B), and intrinsic UII expression. We analyzed serum levels of cartilage related and inflammatory markers post-OA. We observed a noticeable amelioration of the MIA-induced knee damage in UII-treated animals after gross morphology examination. Mankin scoring after histopathological stainings revealed a partial prevention of articular tissue damage in UII-treated animals. We found a significant reduction in BMP-2 and NF-kappa B while an increase in intrinsic UII expressions upon exogenous UII injection after immunohistochemical analyses. The Mankin scores were significantly correlated with BMP-2, NF-kappa B, and intrinsic UII levels. There was no significant alteration in serum markers after UII treatment. We are the first group showing the protective effect of UII on the destructed knee joints of osteoarthritic rats by downregulating the BMP-2 and NF-kappa B and upregulating intrinsic UII expressions. To uncover the mechanistic role of UII during OA, further experiments are warranted. [GRAPHICS] .
dc.identifier.doi10.1007/s10989-022-10448-4
dc.identifier.issn1573-3149
dc.identifier.issn1573-3904
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85135611044
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s10989-022-10448-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10985
dc.identifier.volume28
dc.identifier.wosWOS:000838076200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Peptide Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOsteoarthritis
dc.subjectUrotensin-Ii
dc.subjectCartilage Destruction
dc.subjectMonosodium Iodoacetate
dc.subjectBmp-2
dc.subjectNf-Kappa B
dc.subjectArticular-Cartilage
dc.subjectGene-Expression
dc.subjectReceptor
dc.subjectBone
dc.subjectApoptosis
dc.subjectFibrosis
dc.subjectPathophysiology
dc.subjectOverexpression
dc.subjectInterleukin-6
dc.subjectPeptide
dc.titleUrotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
dc.typeArticle

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