An epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010

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dc.authorscopusid6603040523
dc.authorscopusid26536840100
dc.authorscopusid50461548200
dc.authorscopusid6602822048
dc.authorscopusid24068634800
dc.authorscopusid6504668181
dc.authorscopusid12752983500
dc.contributor.authorTurgut, Nilda
dc.contributor.authorSaraçoğlu Varol, Gamze
dc.contributor.authorKat, Selahattin
dc.contributor.authorBalcı, Kemal
dc.contributor.authorGüldiken, Babürhan Feyzullah
dc.contributor.authorBirgili, Özlem
dc.contributor.authorKabayel, Levent
dc.date.accessioned2022-05-11T14:12:40Z
dc.date.available2022-05-11T14:12:40Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.description.abstractObjective: The aim of the study was to investigate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Thrace, Turkey in a five-year time period (2006-2010). Methods: Study population included residents of three provinces (Edirne, Tekirdag, Kirklareli) in the Thrace region. Cases were ascertained from all of the neurologic centers and hospitals of these provinces. Demographic and clinical information was collected for each patient. Newly diagnosed ALS patients who are fulfilling the El Escorial revised diagnostic criteria were enrolled into the study. Results: We identified a total of 145 patients (93 males, 52 females). The mean age at diagnosis was 57.0 +/- 13.6. According to El Escorial criteria, 60.0% of the cases were definite ALS, 24.8% were probable, and 15.2% were possible ALS. Thirty-two cases were bulbar (22.1%), 113 cases (77.9%) were spinal onset. Mean time delay from onset to diagnosis was 12.0 +/- 11.2 months. Age-gender standardized incidence rates with reference to Turkey, USA 2008 census were 1.9 (95% confidence interval (CI), 1.8-2.1), 1.9 (95%CI, 1.8-2.2) for overall. There were 112 living ALS patients at the end of the study. Crude point prevalence was calculated as 7.3 per 100,000 population (95%CI, 5.9-8.7). Conclusions: This is the first study to provide fundamental data about demographic and clinical characteristics about ALS in Thrace region of Turkey. Incidence and prevalence of ALS in Thrace region of Turkey appear to be comparable with European countries.
dc.identifier.doi10.1080/21678421.2018.1525403
dc.identifier.endpage106
dc.identifier.issn2167-8421
dc.identifier.issn2167-9223
dc.identifier.issue45323en_US
dc.identifier.pmid30468083
dc.identifier.scopus2-s2.0-85057345513
dc.identifier.scopusqualityQ1
dc.identifier.startpage100
dc.identifier.urihttps://doi.org/10.1080/21678421.2018.1525403
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5635
dc.identifier.volume20
dc.identifier.wosWOS:000467740300013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Nilda
dc.institutionauthorSaraçoğlu Varol, Gamze
dc.institutionauthorBirgili, Özlem
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmyotrophic lateral sclerosis
dc.subjectepidemiology
dc.subjectincidence
dc.subjectprevalence
dc.subjectMotor-Neuron Disease
dc.subjectAls
dc.subjectPopulation
dc.subjectSusceptibility
dc.subjectDiagnosis
dc.subjectSurvival
dc.subjectEngland
dc.titleAn epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010
dc.typeArticle

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