Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder

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dc.authorscopusid25633859900
dc.authorscopusid29067508300
dc.authorscopusid55315126400
dc.authorscopusid23968920100
dc.authorscopusid57195962064
dc.authorscopusid36523620300
dc.authorscopusid27967486000
dc.contributor.authorBaykal, S.
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorGüzel, S.
dc.contributor.authorAbbak, Özlem
dc.contributor.authorPotas, Nihan
dc.contributor.authorDonma, Mustafa Metin
dc.date.accessioned2022-05-11T14:02:51Z
dc.date.available2022-05-11T14:02:51Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractAttention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders of childhood and characterized by inattention, hyperactivity, and impulsivity. ADHD is a neurodevelopmental disorder, and its etiology has not yet been determined precisely. Orexin A is thought to play an important role in different forms of learning, memory, and attention. Despite its importance in attention and learning, no study has investigated serum orexin levels in patients with ADHD. In the present study, we aimed to compare serum orexigenic neuropeptides such as orexin A and orexin B, neuropeptide Y, and ghrelin between drug naive children with ADHD and healthy children. Fifty-six drug-naive children with ADHD and 40 healthy controls were enrolled in the study. After comparison of serum orexin A and orexin B, neuropeptide Y, and ghrelin, we found that serum orexin A levels were significantly lower in the ADHD group (p = 0.001). Furthermore, serum orexin A levels were compared between ADHD subgroups. Orexin A levels were significantly lower in the inattentive subtype compared with the hyperactive subtype and combined subtype (p = 0.009). Our results indicate that orexin A might be a neurobiological etiological factor in ADHD, particularly associated with attention symptoms. The present study is the first to demonstrate decreased serum orexin A levels in drug-naive children with ADHD. Further studies are needed to confirm our results and to show the effects of treatments involving orexin A in patients with ADHD. © 2019, Fondazione Società Italiana di Neurologia.
dc.description.sponsorshipNKUBAP.02
dc.description.sponsorshipFunding The present study was supported by Tekirdağ Namık Kemal University Scientific Research Community (Grant Number: NKUBAP.02.GA.17.09)
dc.identifier.doi10.1007/s10072-018-3692-8
dc.identifier.endpage602
dc.identifier.issn1590-1874
dc.identifier.issue3en_US
dc.identifier.pmid30617449
dc.identifier.scopus2-s2.0-85059674816
dc.identifier.scopusqualityQ1
dc.identifier.startpage593
dc.identifier.urihttps://doi.org/10.1007/s10072-018-3692-8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4513
dc.identifier.volume40
dc.identifier.wosWOS:000462505300020
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaykal, S.
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorGüzel, S.
dc.institutionauthorAbbak, Özlem
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherSpringer-Verlag Italia s.r.l.
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAttention
dc.subjectEtiology
dc.subjectHyperactivity
dc.subjectNeurobiology
dc.subjectOrexin
dc.subjectghrelin
dc.subjectneuropeptide Y
dc.subjectorexin A
dc.subjectorexin B
dc.subjectghrelin
dc.subjectneuropeptide Y
dc.subjectorexin
dc.subjectadolescent
dc.subjectArticle
dc.subjectattention deficit disorder
dc.subjectattention disturbance
dc.subjectblood sampling
dc.subjectchild
dc.subjectChild Behavior Checklist
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneurobiology
dc.subjectpeptide analysis
dc.subjectpreschool child
dc.subjectprotein blood level
dc.subjectprotein localization
dc.subjectsemi structured interview
dc.subjectattention deficit disorder
dc.subjectblood
dc.subjectchecklist
dc.subjectnonparametric test
dc.subjectpsychological rating scale
dc.subjectAdolescent
dc.subjectAttention Deficit Disorder with Hyperactivity
dc.subjectChecklist
dc.subjectChild
dc.subjectFemale
dc.subjectGhrelin
dc.subjectHumans
dc.subjectMale
dc.subjectNeuropeptide Y
dc.subjectOrexins
dc.subjectPsychiatric Status Rating Scales
dc.subjectStatistics, Nonparametric
dc.titleDecreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder
dc.typeArticle

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