Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats

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dc.authoridTAVACI, Taha/0000-0002-8284-8317
dc.authorwosidKeskin, Halil/GLQ-8622-2022
dc.authorwosidTAVACI, TAHA/AID-7670-2022
dc.contributor.authorKeskin, Halil
dc.contributor.authorTavacı, Taha
dc.contributor.authorHalıcı, Hamza
dc.contributor.authorYüksel, Tuğba Nurcan
dc.contributor.authorÖzkaraca, Mustafa
dc.contributor.authorBilen, Arzu
dc.contributor.authorHalıcı, Zekai
dc.date.accessioned2023-04-20T08:01:20Z
dc.date.available2023-04-20T08:01:20Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground A sepsis model was created, induced by cecal ligation and puncture (CLP), in juvenile rat groups. Milrinone (MIL), which is known to have a modulatory effect on pro-inflammatory cytokines, was administered to the designated rat groups in the early period before severe sepsis developed. The study was aimed at investigating the possible protective effects of milrinone on the lung and kidney tissues of rats in the late phase of sepsis. Methods The rat pups were divided into seven groups with six animals in each group: (1) healthy rats who received no drug; (2) CLP-S12 (sacrificed at hour 12); (3) CLP-S24 (sacrificed at hour 24); (4) CLP-MIL1-S12 (administered with 0.5 mg/kg milrinone at hour 1 and sacrificed at hour 12); (5) CLP-MIL1-S24 (administered with 0.5 mg/kg milrinone at hour 1 and sacrificed at hour 24): (6) CLP-MIL12-S24 (administered with 0.5 mg/kg milrinone at hour 12 and sacrificed at hour 24), (7) and CLP-MIL1,12-S24 (administered with 0.5 mg/kg milrinone at hours 1 and 12 and sacrificed at hour 24). Results Significant differences were found between the early and late administration of milrinone in terms of both molecular and histopathological results. The results showed that the tissues were significantly preserved in the groups in which milrinone had been started in the early period compared to the sepsis control groups and the groups in which milrinone had been started in the late period. Conclusions In addition to the positive inotropic effects of milrinone, its immunomodulatory properties that result in decreased cytokine storm can be beneficial during early period of sepsis.
dc.identifier.doi10.1111/ped.14917
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue1en_US
dc.identifier.pmid34242458
dc.identifier.scopus2-s2.0-85126439609
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1111/ped.14917
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10875
dc.identifier.volume64
dc.identifier.wosWOS:000783624100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYüksel, Tuğba Nurcan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEarly Administration
dc.subjectImmunomodulatory Effect
dc.subjectJuvenile Rats
dc.subjectMilrinone
dc.subjectPediatric Sepsis
dc.subjectIntercellular-Adhesion Molecule-1
dc.subjectInflammatory Response Syndrome
dc.subjectSeptic Shock
dc.subjectPhosphodiesterase Inhibitors
dc.subjectSystemic Inflammation
dc.subjectPediatric-Patients
dc.subjectOrgan Dysfunction
dc.subjectExpression
dc.subjectKnockout
dc.subjectCamp
dc.titleEarly administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats
dc.typeArticle

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