Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin (retinoic acid) exposure

Basit Öğe Kaydı
dc.authorid0000-0003-0000-5568
dc.authorscopusid6506061779
dc.authorscopusid41862830000
dc.authorscopusid24436194200
dc.authorscopusid24075279000
dc.authorscopusid23968920100
dc.authorscopusid27867662800
dc.authorscopusid56223188000
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidErfan, Gamze/W-8139-2018
dc.contributor.authorAbalı, Remzi
dc.contributor.authorYüksel, Mehmet Aytaç
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÇelik, Cem
dc.contributor.authorGüzel, Savaş
dc.contributor.authorErfan, Gamze
dc.contributor.authorŞahin, Önder
dc.date.accessioned2022-05-11T14:07:40Z
dc.date.available2022-05-11T14:07:40Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.description.abstractIsotretinoin is a retinoid widely used for the treatment of severe nodulocystic acne. Although it has broad side effects, there is no well-designed study about its effects on the ovary. This study investigated possible toxic effects of isotretinoin on female gonads. A total of 30 female rats were randomly divided into three equal groups according to the dose of isotretinoin they were administered: 0 mg/kg/day (group 1), 7.5 mg/kg/day (group 2) or 15 mg/kg/day (group 3). Thirty days after the treatment, the effects of isotretinoin on the ovaries were evaluated with serum anti-Mullerian hormone (AMH) concentrations, apoptosis by TUNEL assay and immunohistochemical observations by proliferating cell nuclear antigen (PCNA). The percentage of atretic follicles was calculated for each stage of folliculogenesis. The serum AMH concentrations were found to be lower in both isotretinoin groups. The percentage of atretic follicles in both isotretinoin groups was higher than the control. The number of PCNA-positive granulosa cells was decreased in the isotretinoin groups. The number of ovarian follicles with apoptotic granulosa cells was increased in the experimental groups. These data are the first to identify that exposure of isotretinoin may be responsible for decreased ovarian reserve and toxic effects on rat ovaries. RBMOnline Crown Copyright (C) 2013. Published by Elsevier Ltd. All rights reserved.
dc.description.sponsorshipNamik Kemal UniversityNamik Kemal University
dc.description.sponsorshipThis study was supported by Namik Kemal University Research Funding.
dc.identifier.doi10.1016/j.rbmo.2013.04.010
dc.identifier.endpage191
dc.identifier.issn1472-6483
dc.identifier.issn1472-6491
dc.identifier.issue2en_US
dc.identifier.pmid23768617
dc.identifier.scopus2-s2.0-84881143094
dc.identifier.scopusqualityQ1
dc.identifier.startpage184
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2013.04.010
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5172
dc.identifier.volume27
dc.identifier.wosWOS:000324161100016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAbalı, Remzi
dc.institutionauthorÇelik, Cem
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErfan, Gamze
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofReproductive Biomedicine Online
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanti-Mullerian hormone
dc.subjectapoptosis
dc.subjectisotretinoin
dc.subjectovarian reserve
dc.subjecttoxicity
dc.subjectatretic follicle
dc.subjectAnti-Mullerian Hormone
dc.subject13-Cis-Retinoic Acid
dc.subjectGene-Expression
dc.subjectApoptosis
dc.subjectWomen
dc.subjectAcne
dc.subjectFollicles
dc.subjectCells
dc.subjectSpermatogenesis
dc.subjectChemotherapy
dc.titleDecreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin (retinoic acid) exposure
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5172.pdf
Boyut:
1.54 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu