Clinical and pathological features of patients with resected synovial sarcoma: A multicenter retrospective analysis of the Anatolian Society of Medical Oncology

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dc.authorid0000-0002-4833-6721
dc.authorscopusid8666331800
dc.authorscopusid56145819800
dc.authorscopusid56145167700
dc.authorscopusid24504259900
dc.authorscopusid56145279500
dc.authorscopusid55981569100
dc.authorscopusid56145546100
dc.authorwosidDurnalı, Ayşe/ABC-2229-2021
dc.authorwosidKucukoner, Mehmet/E-1162-2013
dc.contributor.authorTarkan, Yetişyiğit
dc.contributor.authorErkan, Arpacı
dc.contributor.authorSelçuk, Erdoğan Şeber
dc.contributor.authorMehmet, Küçüköner
dc.contributor.authorKöş, Fahriye Tuğba
dc.contributor.authorUysal Sönmez, Özlem
dc.contributor.authorMahmut, Gümüş
dc.date.accessioned2022-05-11T14:40:55Z
dc.date.available2022-05-11T14:40:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractBackground: Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. Aims: We aimed to evaluate the factors affecting the outcomes of SS patients in the adjuvant setting. Patients and Methods: In this Turkish multicenter study, we assessed the data of 69 SS patients regarding prognostic factors for SS patients retrospectively. Results: Our study included 69 localized SS patients (38 males and 31 females) with a median age of 34.5 years (minimum-maximum: 14-68 years). Overall survival (OS) and disease free survival (DFS) rates for 5 years were 64% and 25%, respectively. All patients under went surgical treatment; 64 patients were treated with a wide excision and 5 patients had an amputation. According to the univariate analysis, adverse prognostic factors for OS were male sex, higher mitotic activity, high Ki-67 levels, trunk localization and inadequate surgical margins. In multivariate analysis, none of these factors had independent significant association with OS. Prognostic factors for DFS; in the univariate analysis were higher mitotic activity, high Ki-67 levels and inadequate surgical margins. Only higher mitotic activity (>= 10 high-power field) was significantly associated with worse DFS in the multivariate analysis (hazard ratio: 0.30, % confidence interval: 0.11-0.80, P = 0.017). Conclusion: Our study confirms that high mitotic activity is significantly associated with decreased DFS. The question of whether the chemotherapy provides a survival advantage in patients having adverse prognostic factors requires confirmation in randomized trials.
dc.identifier.doi10.4103/0973-1482.131381
dc.identifier.endpage78
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue1en_US
dc.identifier.pmid24762490
dc.identifier.scopus2-s2.0-84899692683
dc.identifier.scopusqualityQ3
dc.identifier.startpage73
dc.identifier.urihttps://doi.org/10.4103/0973-1482.131381
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8971
dc.identifier.volume10
dc.identifier.wosWOS:000335372300015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthoryazarlar
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKi-67
dc.subjectmitotic activity
dc.subjectsynovial sarcoma
dc.subjectPrognostic-Factors
dc.subjectTendosynovial Sarcoma
dc.subjectChemotherapy
dc.subjectOutcomes
dc.subjectTumors
dc.subjectExtremities
dc.subjectSurvival
dc.titleClinical and pathological features of patients with resected synovial sarcoma: A multicenter retrospective analysis of the Anatolian Society of Medical Oncology
dc.typeArticle

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