EFFECT OF BREAST CANCER AND BREAST CANCER TREATMENT ON THE BLOOD SERUM CONCENTRATIONS OF TRACE ELEMENTS AND SELENOPROTEINS

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dc.authorscopusid56562766600
dc.authorscopusid56562993900
dc.authorscopusid33867696300
dc.authorscopusid56563019100
dc.authorscopusid8713588200
dc.authorscopusid56619899500
dc.authorscopusid25632114400
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.contributor.authorÖğüt, Selim
dc.contributor.authorBahtiyar, Nurten
dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorCinemre, Fatma Behice
dc.contributor.authorAydemir, Birsen
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorBektaş, Muhammet
dc.date.accessioned2023-04-20T08:02:29Z
dc.date.available2023-04-20T08:02:29Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractTrace elements (TEs) playing critical roles in chemical events that occur at the cellular level in the body are necessary for biological processes in human health. The role of TEs and selenoproteins and their relationship with breast cancer (BC) have not been studied thoroughly and therefore remain relatively unknown. Our study aimed to investigate possible changes in the serum selenoproteins (Glutathione Peroxidase 1 (GPX1), Glutathione Peroxidase 6 (GPX6), Selenoprotein F (Sel-F), Selenoprotein H (Sel-H), Selenoprotein S (Sel-S), Selenoprotein V (Sel-V), Selenoprotein M (Sel-M)), and TEs (Se, Zn, Mn, Cu, and Fe) levels, and TEs ratios (Fe/Se, Fe/Zn, Fe/Mn, Cu/Se, Cu/Zn, and Cu/Mn) in patients with BC before and after treatment (surgery, radiotherapy, and chemotherapy), and to evaluate the results in the patient groups with healthy controls. A total of 35 patients with BC and 25 healthy subjects were included in the study. Blood samples were collected from the patient group on the day prior to treatment, and on the day treatment was completed. Serum GPX1, GPX6, Sel-F, Sel-H, and Sel-S levels were decreased in both before and after treatment groups compared to the control. The treatment of BC resulted in increasing the concentration of Sel-V compared to before treatment levels. The treatment of BC resulted in lowering serum Se, Zn, and Fe concentrations compared to before treatment levels. Also, serum Se, Zn, and Fe levels were decreased in both before and after treatment groups compared to the control. The ratios of Cu/Se, Cu/Zn, and Cu/Mn were increased after treatment compared to the values before treatment. Cu/Se and Cu/Zn ratios were increased, but Fe/Mn ratios were decreased after treatment compared to healthy control. This study indicates that changes in serum levels of TEs such as Zn, Mn, Cu, and Se, as well as their ratios and selenoproteins, may be related to the treatments of BC. Further studies are required to clarify the exact specific mechanisms involved in the status of TEs and selenoproteins in therapeutic strategies of BC.
dc.description.sponsorshipResearch Fund of the University of Health Sciences, Bakirkoy Sadi Konuk Training and Research Hospital
dc.description.sponsorshipThis study was partly supported by the Research Fund of the University of Health Sciences, Bakirkoy Sadi Konuk Training and Research Hospital.
dc.identifier.doi10.5601/jelem.2022.27.1.2216
dc.identifier.endpage302
dc.identifier.issn1644-2296
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85131885447
dc.identifier.scopusqualityQ4
dc.identifier.startpage289
dc.identifier.urihttps://doi.org/10.5601/jelem.2022.27.1.2216
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10963
dc.identifier.volume27
dc.identifier.wosWOS:000806407800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMordeniz, Cengiz
dc.institutionauthorKızıller, Ali Riza
dc.language.isoen
dc.publisherPolish Society Magnesium Research
dc.relation.ispartofJournal of Elementology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Cancer
dc.subjectTreatment
dc.subjectSelenoproteins
dc.subjectSelenium
dc.subjectZinc
dc.subjectCopper
dc.subjectIron
dc.subjectManganese
dc.subjectSelenium Supplementation
dc.subjectNutritional Prevention
dc.subjectZinc Concentrations
dc.subjectProstate-Cancer
dc.subjectCell Carcinoma
dc.subjectRisk
dc.subjectCopper
dc.subjectExpression
dc.subjectBenign
dc.subjectTissues
dc.titleEFFECT OF BREAST CANCER AND BREAST CANCER TREATMENT ON THE BLOOD SERUM CONCENTRATIONS OF TRACE ELEMENTS AND SELENOPROTEINS
dc.typeArticle

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