Curcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic rats

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dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.date.accessioned2022-05-11T14:41:26Z
dc.date.available2022-05-11T14:41:26Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractScope: The present study was designed to examine the protective and antioxidative effects of curcumin (Cur) on streptozotocin (STZ) induced testicular damage, apoptotic germ cell death, and oxidative stress. Methods and resultsDiabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the Cur-treated group were given Cur (100 mg/kg) once a day intragastrik for 8 weeks starting 3 days prior to STZ injection. Cur treatment significantly decreased the elevated tissue malondialdehyde levels and increased the reduced superoxide dismutase, and glutathione peroxidase enzyme activities in testis tissues samples. The Cur-treated rats in the diabetic group showed an improved histological appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling and there was a rise in the expression of proliferating cell nuclear antigen in testis tissues of Cur-treated rats in the diabetic group. ConclusionThese results demonstrate that Cur attenuated testicular damage in diabetic rats by decreasing oxidative stress.
dc.identifier.doi10.1002/mnfr.201200170
dc.identifier.endpage1585
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.issue9en_US
dc.identifier.pmid22930655
dc.identifier.scopus2-s2.0-84883376154
dc.identifier.scopusqualityQ1
dc.identifier.startpage1578
dc.identifier.urihttps://doi.org/10.1002/mnfr.201200170
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9181
dc.identifier.volume57
dc.identifier.wosWOS:000327666600008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofMolecular Nutrition & Food Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptozis
dc.subjectCurcumin
dc.subjectDiabetes
dc.subjectOxidative stress
dc.subjectTestis
dc.subjectFree-Radicals
dc.subjectSeminiferous Tubules
dc.subjectNuclear Antigen
dc.subjectTestis
dc.subjectInjury
dc.subjectMalondialdehyde
dc.subjectAntioxidant
dc.subjectPeroxidase
dc.subjectParameters
dc.subjectQuercetin
dc.titleCurcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic rats
dc.typeArticle

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