Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

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dc.authorscopusid23988616500
dc.authorscopusid57208880300
dc.authorscopusid15764510600
dc.authorscopusid25932306600
dc.authorscopusid55881189500
dc.authorscopusid54892706700
dc.contributor.authorAlbayrak, Hülya
dc.contributor.authorFazlioğlu, Nevin
dc.contributor.authorBatar, Bahadır
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorOran, Mustafa
dc.contributor.authorAltıntaş, Nejat
dc.date.accessioned2023-04-20T08:01:12Z
dc.date.available2023-04-20T08:01:12Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Although psoriasis and obstructive sleep apnea syndrome (OSAS) are associated with systemic inflammation, studies on their potential bilateral relationship are not sufficient. Aim: To investigate vitamin D levels and receptor gene polymorphisms in patients with OSAS and psoriasis and the associations with these diseases. Material and methods: One hundred thirty-seven patients included in the study consisted of 4 different groups: group 1, those with both diseases; group 2, those with OSAS only; group 3, patients with psoriasis only; and group 4, healthy controls. The patients??? serum calcium, phosphorus, AHI, Epworth Sleepiness Scale, Psoriasis Area Severity Index, and VDR TagI, ApaI, BsmI polymorphisms were compared. Results: Vitamin D levels of groups 1, 2 and 3 were found to be lower than in controls. There was no statistically significant correlation between VDR TagI, ApaI, BsmI gene polymorphisms of the groups. Vitamin D levels were significantly higher in patients with heterozygous ApaI genotype (A/C) compared to patients with normal (A/A) or homozygous mutant (C/C) genotype (p < 0.05). No relationship was determined between VDR TagI, ApaI, BsmI, and the other parameters. Conclusions: In our study, 1,25(OH)2-vitamin D3 levels were significantly lower in all disease groups compared to the control group. Although there is no difference between the groups in terms of VDR gene polymorphism, we think that there may be a bidirectional relationship between these diseases based on the low vitamin D levels.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects Coordination Unit [NKUBAP.02, 18.188]
dc.description.sponsorshipA this study was supported by Namik Kemal University Scientific Research Projects Coordination Unit (Project Number NKUBAP.02.GA.18.188).
dc.identifier.doi10.5114/ada.2021.106031
dc.identifier.endpage383
dc.identifier.issn1642-395X
dc.identifier.issn2299-0046
dc.identifier.issue2en_US
dc.identifier.pmid35645681
dc.identifier.scopus2-s2.0-85130877112
dc.identifier.scopusqualityQ3
dc.identifier.startpage375
dc.identifier.urihttps://doi.org/10.5114/ada.2021.106031
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10789
dc.identifier.volume39
dc.identifier.wosWOS:000798157800021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Hülya
dc.institutionauthorFazlioğlu, Nevin
dc.institutionauthorBatar, Bahadır
dc.institutionauthorYanık, Mehmet Emin
dc.institutionauthorAltıntaş, Nejat
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPsoriasis
dc.subjectObstructive Sleep Apnea Syndrome
dc.subjectVitamin D
dc.subjectVdr Polymorphism
dc.subjectD-Receptor Gene
dc.subjectSerum Concentration
dc.subjectAssociation
dc.subjectPolymorphism
dc.subjectRisk
dc.subjectDisease
dc.subjectDeficiency
dc.subjectGenotypes
dc.titleRelationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients
dc.typeArticle

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