The Evaluation of the Relationship between Bladder Cancer and Oxidative Stress Using NRF-2/KEAP-1 Pathway, Zinc and Copper Levels

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dc.authorscopusid55608201600
dc.authorscopusid8416588900
dc.authorscopusid36151868000
dc.authorscopusid23052928300
dc.contributor.authorDoğan, Cağrı
dc.contributor.authorYazıcı, Cenk Murat
dc.contributor.authorAkgül, Murat
dc.contributor.authorTürker, Polat
dc.date.accessioned2022-05-11T14:04:58Z
dc.date.available2022-05-11T14:04:58Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: It has been shown that Copper and Zinc contribute to the structure of the antioxidant enzymes. In addition, NRF-2 and KEAP-1 complex have a powerful effect on the intracellular organization of the antioxidants. We evaluated the relation of Copper, Zinc, NRF-2, and KEAP-1 complex regarding the oxidative stress with tumor stage - grade in patients with bladder cancer. Materials and Methods: A total of 52 patients (32 bladder cancer and 20 control group) were included in the study. The demographic properties of groups were identical. Serum NRF-2, KEAP-1, Cu, and Zn levels were compared by ELISA method between the groups, and tissue NRF-2, KEAP-1, Cu and Zn levels were evaluated also by ELISA method in cancer patients. Results: Serum levels of NRF-2 and KEAP-1 of the bladder cancer patients were found to be higher than the control group (p = 0.004 and p = 0.001, respectively). On the other hand serum levels of Copper and Zinc were found to be lower than the control group (p = 0.008 and p = 0.001, respectively). However, the subgroup analysis according to the stages and grades of the tumour showed no difference. The Copper level obtained from the tissue analysis was detected to be considerably decreased with tumour stage and grade. Conclusion: Bladder cancer patients had higher serum NRF-2 and KEAP-1 levels and lower serum Copper and Zinc levels. In addition, the Copper levels decreased with the tumour stage and grade. Studies with larger number of patients are needed to demonstrate the efficacy of these markers. © 2021. Urology Journal. All Rights Reserved.
dc.description.sponsorshipNKU-BAP.00.20, TU.15.01
dc.description.sponsorshipACKNOWLEDGEMENT This investigation was supported by Tekirdağ Namık Kemal University Scientific Research Projects Committee with project number NKU-BAP.00.20.TU.15.01.
dc.identifier.doi10.22037/uj.v18i.6439
dc.identifier.endpage428
dc.identifier.issn1735-1308
dc.identifier.issue4en_US
dc.identifier.pmid33840087
dc.identifier.scopus2-s2.0-85115736301
dc.identifier.scopusqualityQ3
dc.identifier.startpage422
dc.identifier.urihttps://doi.org/10.22037/uj.v18i.6439
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4851
dc.identifier.volume18
dc.identifier.wosWOS:000705029100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Cağrı
dc.institutionauthorYazıcı, Cenk Murat
dc.institutionauthorAkgül, Murat
dc.institutionauthorTürker, Polat
dc.language.isoen
dc.publisherUrology and Nephrology Research Centre
dc.relation.ispartofUrology Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbladder cancer
dc.subjectKEAP-1
dc.subjectNRF-2
dc.subjecturinary markers
dc.subjectantioxidant
dc.subjectcopper
dc.subjectzinc
dc.subjectbladder tumor
dc.subjecthuman
dc.subjectoxidative stress
dc.subjectAntioxidants
dc.subjectCopper
dc.subjectHumans
dc.subjectOxidative Stress
dc.subjectUrinary Bladder Neoplasms
dc.subjectZinc
dc.titleThe Evaluation of the Relationship between Bladder Cancer and Oxidative Stress Using NRF-2/KEAP-1 Pathway, Zinc and Copper Levels
dc.typeArticle

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