Expression of voltage gated potassium channel ether a go-go in pituitary adenomas of patients with acromegaly: A preliminary study

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dc.authorid0000-0002-0920-6895
dc.authorid0000-0001-8084-848X
dc.authorid0000-0001-5584-4954
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.authorwosidZuhur, Sayid/AAC-6839-2020
dc.authorwosidÖztürk, Feyza Yener/AAL-3013-2020
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorÖzkayalar, Hanife
dc.contributor.authorKuzu, İdris
dc.contributor.authorÖztürk, Feyza Yener
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorTanık, Canan
dc.contributor.authorAltuntaş, Yüksel
dc.date.accessioned2022-05-11T14:39:52Z
dc.date.available2022-05-11T14:39:52Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To determine immunohistochemical expression of Eag1 in pituitary adenomas of patients with acromegaly and to assess the correlation between Eag1 expression with cavernous sinus invasion, tumoral Ki-67 labeling index (LI), age and gender of the patients. METHODS: The paraffin embedded pituitary adenoma tissue sections of 28 patients with acromegaly who were diagnosed as monohormonal growth hormone (GH) secreting adenomas were immunostained for Eag1 using the avidin-biotin-peroxidase complex method. Eag1 immunoreactivity was scored according to the extensity of the cytoplasm and cell membrane immunoreactivity for Eag1 (score 1 = <10%, score 2 = 10-25%, score 3 = 25-50% and score 4 = >50% of the adenoma cells showed immunoreactivity for Eag1, respectively). RESULTS: Overall, GH secreting pituitary adenomas displayed diverse levels of Eag1 immunoreactivity, however, 64% of the adenomas displayed a strong Eag1 immunoreactivity (score 3 and 4). Five of the tumors displayed Eag1 immunoreactivity score 1, 5 displayed score 2, 10 displayed score 3 and 8 displayed score 4, respectively. No correlation was found between Eag1 immunoreactivity with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. CONCLUSIONS: Our results suggest Eag1 is strongly expressed in the majority of GH secreting pituitary adenomas. However, we could not find any correlation between immunoreactivity of Eag1 with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. Further studies with larger sample sizes are required to demonstrate the role of Eag1 on tumorigenesis, angiogenesis, invasion and response to the treatment in GH secreting pituitary adenomas.
dc.identifier.endpage170
dc.identifier.issn0172-780X
dc.identifier.issn2354-4716
dc.identifier.issue2en_US
dc.identifier.pmid26071586
dc.identifier.scopus2-s2.0-84937417801
dc.identifier.scopusqualityQ4
dc.identifier.startpage165
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8775
dc.identifier.volume36
dc.identifier.wosWOS:000356968700014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.institutionauthorElbüken, Gülşah
dc.language.isoen
dc.publisherMaghira & Maas Publications
dc.relation.ispartofNeuroendocrinology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEag1
dc.subjectacromegaly
dc.subjectpituitary
dc.subjectKi-67
dc.subjectcavernous sinus
dc.subjectKi-67 Labeling Index
dc.subjectK+ Channels
dc.subjectEag1
dc.subjectProliferation
dc.subjectCytoskeleton
dc.subjectImipramine
dc.titleExpression of voltage gated potassium channel ether a go-go in pituitary adenomas of patients with acromegaly: A preliminary study
dc.typeArticle

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