The relationship of serum asymmetric dimethylarginine concentrations and lung involvement in patients with COVID-19 infection

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dc.contributor.authorEmlek, Nadir
dc.contributor.authorYılmaz, Ahmet Seyda
dc.contributor.authorErgül, Elif
dc.contributor.authorGündoğdu, Hasan
dc.contributor.authorArpa, Medeni
dc.contributor.authorKoç, Haldun
dc.contributor.authorAydın, Cihan
dc.date.accessioned2022-05-11T14:40:04Z
dc.date.available2022-05-11T14:40:04Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractAim: COVID-19 infections the tissue through angiotensin converting enzyme 2 receptor, which is also expressed on endothelial cells. Endothelial dysfunction may be associated with lung involvement. Asymmetric dimethylarginine (ADMA) is an indirect marker of endothelial dysfunction. The aim of our study was to evaluate ADMA concentrations and to identify its association with lung involvement in patients with COVID 19 disease. Methods: We included 42 patients with COVID-19 infection and lung involvement (Group 1). Forty-two age and sex matched patients without pneumonia acted as the control group (Group 2). All patients gave blood samples for ADMA at the 1st month control visit after discharge. We compared C-reactive protein (CRP) and ADMA concentrations in addition to routine biochemical parameters between groups. Results: Patients with lung involvement had higher admission glucose, CRP, and ADMA concentrations, and displayed lower hemoglobin concentration and lymphocyte count compared to patients without lung involvement. Although patients with lung involvement had higher ADMA concentrations with respect to those without; plasma ADMA levels were also higher than normal values in control group. Multivariate analysis identified log CRP concentration (OR= 3.047, 95% CI=1.881-5.023, p<0.001) as the independent predictor for lung involvement. And, there was a correlation between ADMA and CRP (r: 0.318, p: 0.003). Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction in COVID-19 patients whether they have pneumonia or not.
dc.identifier.doi10.30714/j-ebr.2021471926
dc.identifier.endpage321
dc.identifier.issn2618-6454
dc.identifier.issn2618-6454
dc.identifier.issue4en_US
dc.identifier.startpage314
dc.identifier.trdizinidTkRnNU1UUTBOQT09
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2021471926
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRnNU1UUTBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8855
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAydın, Cihan
dc.language.isoen
dc.relation.ispartofExperimental Biomedical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe relationship of serum asymmetric dimethylarginine concentrations and lung involvement in patients with COVID-19 infection
dc.typeArticle

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