Bioactive, Pro-Apoptotic-Angiotensin Converting Enzyme Inhibitor Effects and Properties of Ultrasound-Treated Traditional Poppy Vinegar Using the Response Surface Methodology Model

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dc.authoridAadil, Rana Muhammad/0000-0002-0185-0096
dc.authoridYikmis, Seydi/0000-0001-8694-0658
dc.authoridTOKATLI DEMIROK, NAZAN/0000-0003-1936-9337
dc.authoridIlaslan, Kerem/0000-0001-9789-6437
dc.contributor.authorYikmis, Seydi
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorDemirok, Nazan Tokatli
dc.contributor.authorIlaslan, Kerem
dc.contributor.authorAadil, Rana Muhammad
dc.date.accessioned2024-10-29T17:58:32Z
dc.date.available2024-10-29T17:58:32Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractPoppy vinegar with functional properties is a fermented product. This study evaluated traditionally produced poppy vinegar. The study was conducted on poppy vinegar to determine the maximum increase in angiotensin converting enzyme (ACE) inhibitory activity %, total phenolic content (TPC), and radical scavenging activity (DPPH) of the vinegar at different combinations of ultrasound treatment duration (2-14 min) and amplitude (40-100%). The optimal parameters obtained using the response surface methodologies (RSM) were the duration of the ultrasound of 5.5 min and the amplitude of the ultrasound at 57%. When the DPPH values, ACE inhibition %, and TPC and DPPH values obtained with the RSM model were compared with the experimental values, the difference was 9.80, 3.0, and 4.6%, respectively, showing good agreement between actual and predicted values. The higher ultrasound intensities and longer treatment times had a significant effect on antioxidant activity. Poppy vinegar samples significantly induced the apoptosis of lung cancer cells, particularly those stored for 6 and 12 months. The amounts of protocatechuic acid, gallic acid, neohesperidin, hydroxybenzoic acid, resveratrol, rutin, trans-cinnamic acid, quercetin, and flavon in poppy vinegar were determined, which decreased significantly as storage time increased. TPC and TFC were determined to be 90.39 mg of GAE/100 mL and 29.86 mg of TEAC/mL, respectively, and there was no significant change in these bioactive compounds after 6 months of storage. The highest value of ACE inhibitory activity was found at the beginning of the storage period. The present study was the first study to examine the bioactive components, ACE inhibition activity, pro-apoptotic activities, and phenolic composition of traditionally produced ultrasound-treated poppy vinegar during storage. The control of production parameters and the design of ideal poppy vinegar fermentation processes could benefit from this research.en_US
dc.description.sponsorshipBahcesehir Universityen_US
dc.description.sponsorshipThis paper was funded by Bahcesehir University as open access under the Institutional Open Access Agreements.en_US
dc.identifier.doi10.1021/acsomega.4c04342
dc.identifier.endpage34858en_US
dc.identifier.issn2470-1343
dc.identifier.issue32en_US
dc.identifier.pmid39157087en_US
dc.identifier.scopus2-s2.0-85199779726en_US
dc.identifier.startpage34848en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c04342
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14377
dc.identifier.volume9en_US
dc.identifier.wosWOS:001280417700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAscorbic-Aciden_US
dc.subjectMulberryen_US
dc.subjectPhenolicsen_US
dc.titleBioactive, Pro-Apoptotic-Angiotensin Converting Enzyme Inhibitor Effects and Properties of Ultrasound-Treated Traditional Poppy Vinegar Using the Response Surface Methodology Modelen_US
dc.typeArticleen_US

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