RESEARCH The shrinkage effect of formalin on renal cell carcinoma: Does it change the stages

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dc.authoridYazıcı, Cenk Murat/0000-0001-6140-5181
dc.authorwosidYazıcı, Cenk Murat/AAA-4330-2020
dc.contributor.authorAkgül, Murat
dc.contributor.authorArslan, Ayşegül İsal
dc.contributor.authorYazıcı, Cenk
dc.contributor.authorAltın, Enes
dc.contributor.authorÖznur, Meltem
dc.date.accessioned2023-05-06T17:19:33Z
dc.date.available2023-05-06T17:19:33Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjective: To determine the shrinkage effect of formalin on renal cell carcinoma.Method: The retrospective study was conducted from October to November 2020 at Tekirdag Namik Kemal University, Turkey, and comprised all radical and partial nephrectomy cases performed by a single surgeon in a single clinic between January 2014 and August 2020. Pre-operative images and post-operative pathology were reviewed by the same clinician. Pre-operative longest tumour diameter of radiological images and pathological specimens measured after formalin fixation shrinkage were compared, and the effect of the difference between the two measurements on the circumference of the tumour was examined. The formalin-related shrinkage rates of renal tumours according to the tumour size and the tumour types were also analysed. Data was analysed using SPSS 20.Results: Of the 101 cases, 58(57.4%) were of radical and 43(42.6%) of partial nephrectomy. Also, there were 77(76.2%) renal cell carcinoma cases, 22(21.8%) benign renal tumours and 2(1.9%) had other malignant tumours. There were 59(58.4%) males and 42(41.6%) females with an overall mean age of 58.1 +/- 12,2 years (range: 30-82 years). The mean radiological size of the renal tumours was 55.3 +/- 30.4 mm and it was 52.9 +/- 31.6 mm at pathological examination (p>0.05). Conclusion: Formalin fixation of tissues post-surgery caused a difference between the radiological and pathological dimensions. Though the difference was no significant, under-staging due to the shrinkage post-surgery should be considered.
dc.identifier.doi10.47391/JPMA.3107
dc.identifier.endpage2179
dc.identifier.issn0030-9982
dc.identifier.issue11en_US
dc.identifier.pmid37013281
dc.identifier.scopus2-s2.0-85141400446
dc.identifier.scopusqualityQ4
dc.identifier.startpage2175
dc.identifier.urihttps://doi.org/10.47391/JPMA.3107
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11850
dc.identifier.volume72
dc.identifier.wosWOS:000881776500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkgül, Murat
dc.institutionauthorArslan, Ayşegül İsal
dc.institutionauthorYazıcı, Cenk
dc.institutionauthorAltın, Enes
dc.institutionauthorÖznur, Meltem
dc.language.isoen
dc.publisherPakistan Medical Assoc
dc.relation.ispartofJournal Of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal tumours
dc.subjectTissue shrinkage
dc.subjectFormalin
dc.subjectradiological dimension
dc.subjectPathological dimension
dc.subjectTumor Size
dc.subjectIn-Vivo
dc.subjectFixation
dc.subjectCancer
dc.titleRESEARCH The shrinkage effect of formalin on renal cell carcinoma: Does it change the stages
dc.typeArticle

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