Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients

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dc.authorid0000-0003-2420-8415
dc.authorid0000-0003-2645-1988
dc.authorscopusid8713588200
dc.authorscopusid56563019100
dc.authorscopusid23667114900
dc.authorscopusid6508166517
dc.authorscopusid6701406385
dc.authorscopusid36115580500
dc.authorscopusid57190009526
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.contributor.authorAydemir, Birsen
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorVatan, Mehmet Bülent
dc.contributor.authorAkkoyun, Dursun Çayan
dc.date.accessioned2022-05-11T14:41:21Z
dc.date.available2022-05-11T14:41:21Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractObjective: The aim of the present study was to investigate whether copper, zinc and iron levels and copper/zinc, iron/zinc, iron/copper ratios in serum and erythrocytes are associated with lipid oxidation levels, metallothionein-1 (MT-1), and metallothionein-2 (MT-2) levels in plasma in the context of pathogenesis of the mitral chordae tendineae rupture (MCTR). Methods: 65 subjects who were identical in demographic characteristics' were selected for the study; 33 with MCTR patients, and 32 healthy control subjects. The levels of MT-1, MT-2, and malondialdehyde as measure of lipid oxidation, and trace elements were determined by enzyme-linked immunosorbent assay, spectrophotometric method, and inductively coupled plasma optical emission spectrometry, respectively. Results: Serum zinc levels were found to be lower in the patients' group when compared to control group. The copper and iron levels in serum, MT-1, MT-2; malondialdehyde levels in plasma, iron and malondialdehyde levels in erythrocytes; serum copper/zinc and iron/zinc ratios were found to be higher in the patients' group when compared to controls. Conclusions: We conclude that the changes of oxidant antioxidant system balance and trace element status may contribute to the etiopathogenesis of MCTR.
dc.identifier.doi10.5414/TEX01452
dc.identifier.endpage170
dc.identifier.issn0946-2104
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84989267470
dc.identifier.scopusqualityN/A
dc.identifier.startpage162
dc.identifier.urihttps://doi.org/10.5414/TEX01452
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9155
dc.identifier.volume33
dc.identifier.wosWOS:000388286600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherDustri-Verlag Dr Karl Feistle
dc.relation.ispartofTrace Elements and Electrolytes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcopper
dc.subjectzinc
dc.subjectiron
dc.subjectcopper/zinc
dc.subjectiron/zinc
dc.subjectiron/copper
dc.subjectmetallothionein-1
dc.subjectmetallothionein-2
dc.subjectmalondialdehyde
dc.subjectmitral chordae tendineae rupture
dc.subjectOxidative Stress
dc.subjectExpression
dc.subjectDisease
dc.subjectZinc
dc.subjectMice
dc.subjectSelenium
dc.subjectMetals
dc.subjectTissue
dc.titleEvaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients
dc.typeArticle

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