Comparison of the efficacy of the cardiac hypothermia and normothermia to myocardial damage in coronary artery bypass graft surgery with systemic normothermic cardiopulmonary bypass

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dc.authorscopusid6602782113
dc.authorscopusid10139012600
dc.authorscopusid7004591561
dc.authorscopusid24071001900
dc.authorscopusid8254018300
dc.authorscopusid7005322966
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.contributor.authorÇakır, Habib
dc.contributor.authorGür, Özcan
dc.contributor.authorEge, Turan
dc.contributor.authorKunduracilar, H.
dc.contributor.authorKetenciler, S.
dc.contributor.authorDuran, E.
dc.date.accessioned2022-05-11T14:35:56Z
dc.date.available2022-05-11T14:35:56Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractAim. The aim of our research is to investigate the cardiac damage formed by either local cardiac hypothermia or cardiac normothermia technique in patients who undergone isolated coronary artery bypass graft (CABG) surgery. Methods. The total of 40 patients who underwent isolated CABG operation under normothermic cardiopulmonary bypass (CPB) were studied. Patients were randomly divided into two groups as cardiac hypothermia and cardiac normothermia. Myocardial temperature was measured from the interventricular septum before aortic cross-clamp (ACC) (baseline), the ACC 20th minutes (ischemia) and after 20 minutes removal of the ACC (reperfusion). The coronary sinus blood samples were simultaneously obtained from the retrograde cardioplegia cannula while myocardial temperature was being measured. Complement component 3 (C3), complement component 4 (C4), troponin I and tumor necrosis factor-alpha (TNF-alpha) was measured from the coronary sinus blood samples. Results. Myocardial temperature was between 18-28 degrees C (deep hypothermia) during ACC in group 1. Myocardial temperature was over 34 degrees C (normothermia) during ACC in group 2. TNF-alpha values of group 1 for ischemia and reperfusion were higher than group 2, and it was found statistically significant (P<0.05). Conclusion. Myocardial damage was less than in normothermia group according to hypothermia group. The results show that ice-cold blood cardioplegia and local ice treatment of the heart during CPB seems to harm the heart more than warm blood cardioplegia.
dc.identifier.endpage401
dc.identifier.issn0021-9509
dc.identifier.issn1827-191X
dc.identifier.issue3en_US
dc.identifier.pmid23369948
dc.identifier.scopus2-s2.0-84879303260
dc.identifier.scopusqualityQ2
dc.identifier.startpage397
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8307
dc.identifier.volume54
dc.identifier.wosWOS:000320743200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGür, Özcan
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofJournal of Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCoronary artery bypass graft
dc.subjectHypothermia
dc.subjectCardiac disease
dc.subjectAtrial-Fibrillation
dc.subjectOxygen-Consumption
dc.subjectWarm Blood
dc.subjectOff-Pump
dc.subjectCardioplegia
dc.subjectHeart
dc.titleComparison of the efficacy of the cardiac hypothermia and normothermia to myocardial damage in coronary artery bypass graft surgery with systemic normothermic cardiopulmonary bypass
dc.typeArticle

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