Time dependent influence of etonogestrel on the caspase-3 imunereactivity and apoptotic indexes of rat uterus and ovaries

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dc.authorscopusid23986422400
dc.authorscopusid55666290500
dc.authorscopusid6504457722
dc.authorscopusid23986610700
dc.authorscopusid55217339400
dc.authorscopusid6602965000
dc.contributor.authorTaşdemir, Nicel
dc.contributor.authorKılıç, Sevtap
dc.contributor.authorLortlar, Neşe
dc.contributor.authorYüksel, Beril
dc.contributor.authorGöker, Ufuk
dc.contributor.authorÖzakşit, Gülnur
dc.date.accessioned2022-05-11T14:35:50Z
dc.date.available2022-05-11T14:35:50Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractApoptosis is necessary for the balance between cell proliferation and loss. Thirty-six Wistar-Albino rats were subjected to investigate apoptotic effect of widely used implantable progestins on ovarian and uterine tissues. Rats were divided into 6 groups. In the first five groups, we applied etonogestrel (IMP) subcutaneous implants (n = 30). The rats in groups were sacrificed sequentially every 10 days after application. The rats in the last group (n = 6) were accepted as controls. Apoptotic index (AI) values and Caspase-3 immunereactivities of ovaries and uterus were recorded. In IMP groups, AI and Hscore values in stroma and glandular epithelium of uterus, granulosa and teca-lutein cells of the ovary increased with the longer progesterone exposure. Increase in AI and Hscore values were more prominent after 30 days of exposure for teca-lutein cells of ovary. Progestins increased apoptosis in ovaries and uterus by the longer exposure. Apoptosis increased in ovaries by chronic progesterone exposure. The apoptotic effect of progestin on endometrium is clear but long-term systemic application may lead to alterations in ovarian physiology. We evaluated time dependent apoptotic effect of etonogestrel on reproductive physiology and discussed progestins effect from another point of view in this study.
dc.identifier.doi10.3109/09513590.2011.633652
dc.identifier.endpage467
dc.identifier.issn0951-3590
dc.identifier.issue6en_US
dc.identifier.pmid22578029
dc.identifier.scopus2-s2.0-84861081159
dc.identifier.scopusqualityQ2
dc.identifier.startpage463
dc.identifier.urihttps://doi.org/10.3109/09513590.2011.633652
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8256
dc.identifier.volume28
dc.identifier.wosWOS:000304067400014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaşdemir, Nicel
dc.institutionauthorKılıç, Sevtap
dc.institutionauthorYüksel, Beril
dc.institutionauthorGöker, Ufuk
dc.institutionauthorÖzakşit, Gülnur
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectcaspase
dc.subjectovary
dc.subjectprogestins
dc.subjectrat
dc.subjectPeriovulatory Granulosa-Cells
dc.subjectProgesterone-Receptor Antagonists
dc.subjectGrowth-Factor-Beta
dc.subjectEndometrial Hyperplasia
dc.subjectIncrease Apoptosis
dc.subjectFollicle Atresia
dc.subjectCorpus-Luteum
dc.subjectIn-Vitro
dc.subjectLocalization
dc.subjectGonadotropin
dc.titleTime dependent influence of etonogestrel on the caspase-3 imunereactivity and apoptotic indexes of rat uterus and ovaries
dc.typeArticle

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