The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations

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dc.contributor.authorCimci, Murat
dc.contributor.authorBatar, Bahadir
dc.contributor.authorBostanci, Merve
dc.contributor.authorDurmaz, Eser
dc.contributor.authorKarayel, Bahadir
dc.contributor.authorRaimoglou, Damla
dc.contributor.authorGuven, Mehmet
dc.date.accessioned2024-10-29T17:58:21Z
dc.date.available2024-10-29T17:58:21Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIonizing radiation (IR) exposures have increased exponentially in recent years due to the rise in diagnostic and therapeutic interventions. A number of small-scale studies investigated the long-term effect of IR on health workers or immediate effects of IR on patients undergoing catheterization procedures; however, the long-term impact of multiple cardiac catheterizations on DNA damage on a patient population is not known. In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2 & PRIME;-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent & GE; 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent & LE; 2 procedures, documented with the presence of higher level of MN frequency (6.4 & PLUSMN; 4.8 vs. 9.1 & PLUSMN; 4.3, p = 0.002) and elevated serum 8-OHdG levels (33.7 & PLUSMN; 3.8 ng/mL vs. 17.4 & PLUSMN; 1.9 ng/mL, p = 0.001). Besides, OGG1 Ser326Cys and APE1 Asn148Glu heterozygous and homozygous polymorphic types, which are related with DNA repair mechanisms, were significantly associated with MN frequency levels (p = 0.006 for heterozygous and p = 0.001 for homozygous with respect to OGG1 Ser326Cys, p = 0.007 for heterozygous and p = 0.001 for homozygous with respect to APE1 Asn148Glu). There was no significant difference in terms of PARP1 Val762Ala gene polymorphism between two groups.
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University-Cerrahpasa [31436]
dc.description.sponsorshipThe present work was supported by the Scientific Research Project Coordination Unit of Istanbul University-Cerrahpasa. Project No. 31436.
dc.identifier.doi10.1007/s12012-023-09801-w
dc.identifier.endpage283
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue45511en_US
dc.identifier.pmid37458898
dc.identifier.scopus2-s2.0-85164971422
dc.identifier.scopusqualityQ2
dc.identifier.startpage278
dc.identifier.urihttps://doi.org/10.1007/s12012-023-09801-w
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14251
dc.identifier.volume23
dc.identifier.wosWOS:001031393200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofCardiovascular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIonizing radiation
dc.subjectCardiac catheterization
dc.subjectMicronuclei
dc.subjectGenetic polymorphism
dc.titleThe Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
dc.typeArticle

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