Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

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dc.authorscopusid55315126400
dc.authorscopusid29067508300
dc.authorscopusid16242290400
dc.authorscopusid55260348200
dc.authorscopusid57223220574
dc.authorscopusid8240771400
dc.authorscopusid57218290288
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorTokgöz, Y.
dc.contributor.authorBeşer, Ö.F.
dc.contributor.authorDurankuş, R.
dc.contributor.authorÇam, Sebahat
dc.contributor.authorErel, Özcan
dc.date.accessioned2022-05-11T14:05:09Z
dc.date.available2022-05-11T14:05:09Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups. Results: The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group. Conclusion: The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD. © 2021 Taylor & Francis Group, LLC.
dc.identifier.doi10.1080/15513815.2021.1918298
dc.identifier.issn1551-3815
dc.identifier.scopus2-s2.0-85105309174
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/15513815.2021.1918298
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4907
dc.identifier.wosWOS:000646974600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofFetal and Pediatric Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDisulfide
dc.subjectthiol
dc.subjectWilson disease
dc.titleInvestigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease
dc.typeArticle

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