The Role of Serum Apelin Levels in Peripheral Artery Disease

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dc.authorid0000-0002-1503-329X
dc.authorscopusid23391660500
dc.authorscopusid14008084500
dc.authorscopusid55858591400
dc.authorscopusid23968920100
dc.authorwosidYumun, Gunduz/J-5643-2013
dc.contributor.authorYümün, Gündüz
dc.contributor.authorGürkan, Selami
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:04:55Z
dc.date.available2022-05-11T14:04:55Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractApelin is a bioactive mediator released by adipose tissue that can be involved in energy metabolism events and coronary artery disease. This study aims to investigate the role of serum apelin levels in patients with peripheral artery disease (PAD). The present observational case-control study consisted of 100 subjects (50 angiographically proven PAD patients and 50 healthy controls). Serum apelin and apelin receptor (APJ) levels were measured with blood samples. Clinical and laboratory findings were obtained from the hospital database system. The association between serum apelin levels, and PAD was investigated. The number of smokers and subjects with hypertension, coronary artery disease and diabetes mellitus was higher in the PAD group than in the control group (P < 0.05). Mean serum apelin levels were lower in the peripheral artery group than in the control group (mean: 13.94, SD 4.34 vs. mean: 16.79, SD 4.2, P = 0.001). On the other hand, the mean APJ levels were higher in the control group (mean: 36.1, SD 19.1 vs. mean: 27.7, SD 13.1, P = 0.019). There was no statistically significant difference between the two groups (20 (41.6%) vs. 21 (42%), P = 973) regarding the obesity. Our findings revealed that hypertension, smoking and diabetes mellitus rates were higher among patients with PAD. In fact, the lower apelin levels and higher APJ levels were risk factors associated with PAD; the obesity was not related with development of PAD.
dc.description.sponsorshipNamik Kemal University Research FundNamik Kemal University [NKUBAP.02, 18.169]
dc.description.sponsorshipThis study was supported by the Namik Kemal University Research Fund (Project no: NKUBAP.02. GA.18.169).
dc.identifier.doi10.1007/s12262-022-03370-y
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.scopus2-s2.0-85126751846
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1007/s12262-022-03370-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4837
dc.identifier.wosWOS:000771384000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYümün, Gündüz
dc.institutionauthorGürkan, Selami
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPeripheral artery disease
dc.subjectAPJ
dc.subjectApelin levels
dc.subjectRisk-Factors
dc.titleThe Role of Serum Apelin Levels in Peripheral Artery Disease
dc.typeArticle

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