The effect of sucrose consumption on eating behavior and depression during morphine withdrawal period in rats

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dc.contributor.authorAslan, Serkan
dc.contributor.authorKoksalb, Eda
dc.contributor.authorKaraboga, Ihsan
dc.date.accessioned2024-10-29T17:59:09Z
dc.date.available2024-10-29T17:59:09Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractBACKGROUND: Sugary drink and junk food consumption increases during the withdrawal period, leading to subsequent psychological and metabolic alterations. OBJECTIVES: We aimed to investigate the relationship of sucrose consumption with serum insulin levels, leptin levels, brain Dopamine-2 receptor (D2R) expression, food consumption, and anxiety-depression findings in morphine-withdrawal rats. METHODS: Thirty-six male Wistar albino rats were divided into six groups: Control, sucrose-free, 5% sucrose, 10% sucrose, 20% sucrose, and an addiction test. Saline was intraperitoneally injected to the control group, and morphine was intraperitoneally injected to the other groups for 14 days. After 14 days, naloxone was administered to the addiction test group, and addiction symptoms were observed and this group was sacrificed on the same day. Other groups were fed ad libitum with different concentrations of sucrose solution for one week. Behavioral parameters were evaluated at the end of the experiment. Leptin and insulin concentrations in serum and D2R levels in brain tissues were detected using an enzyme-linked immunosorbent assay. D2R concentrations in brain tissues were evaluated utilizing immunohistochemistry. RESULTS: We observed decreased food consumption and increased fluid consumption in rats that consumed sucrose water during the withdrawal period. The level of depression and binge eating behavior was elevated in groups consuming sucrose, and the 10% sucrose group had the highest carbohydrate consumption and anxiety levels. In addition, the 10% sucrose group had the lowest brain D2R expression. The leptin level was highest in the 20% sucrose group. CONCLUSIONS: These results show the possible effects of sugary drinks consumed during the withdrawal period.
dc.description.sponsorshipResearch Fund of the Tekirdag Namik Kemal University [21.304]
dc.description.sponsorshipThis work was supported by Research Fund of the Tekirdag Namik Kemal University. Project Number: (23.GA.21.304)
dc.identifier.doi10.3233/MNM-230072
dc.identifier.endpage122
dc.identifier.issn1973-798X
dc.identifier.issn1973-7998
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85197901732
dc.identifier.scopusqualityQ3
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.3233/MNM-230072
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14646
dc.identifier.volume17
dc.identifier.wosWOS:001263740000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIos Press
dc.relation.ispartofMediterranean Journal of Nutrition and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSucrose
dc.subjectmorphine
dc.subjectwithdrawal
dc.subjectanxiety
dc.subjectdepression
dc.subjectdopamine 2 receptor (D2R)
dc.titleThe effect of sucrose consumption on eating behavior and depression during morphine withdrawal period in rats
dc.typeArticle

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