Osteoprotegerin Plasma Concentrations Are Correlated with Forced Expiratory Volume At 1 Second (Fev1) in Patients with Chronic Obstructive Pulmonary Disease

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dc.authorid0000-0002-3535-5704
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidAvcı, Okan/ABG-8782-2021
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorOran, Mustafa
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorGüzel, Savaş
dc.contributor.authorTopçu, Birol
dc.contributor.authorAvcı, Okan
dc.contributor.authorKüçükyalçın, Volkan
dc.date.accessioned2022-05-11T14:07:36Z
dc.date.available2022-05-11T14:07:36Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractIntroduction: Several inflammatory biomarkers such as 1L-1 beta, IL-6 and TNF-alpha have been evaluated during stable state and exacerbations of chronic obstructive pulmonary disease (COPD), Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor family that inhibits receptor activator of nuclear factor-kappa B ligand (RANKL). OPG mRNA is expressed in the lung and macrophages. The objective of the study was to evaluate the serum level of OPG and its correlation with forced expiratory volume at I second (FEV1) in patients with COPD versus healthy volunteers. Materials and methods: The study was conducted between June 2011 and October 2012 in the pulmonology clinic of the medical school at Namuk Kemal University. Previously diagnosed stable 47 COPD patients and non-smoking gender- and age-matched 23 healthy volunteers were included to the study. Osteoprotegerin levels in the serum were quantified by Biovendor enzyme linked immunosorbent assays. Results: The level of FEV1. on average was 593 +/- 16.9. Plasma OPG concentrations of COPD patients (8.61 +/- 4.4.78 ng/ml. n=47) were higher than those of healthy control group (6.29 +/- 1.36 ng/ml. n=23). The difference was statistically significant (p<0.05). On the other hand, serum OPG levels had a significantly negative correlation with FEV1 (r= - 0.33 p<0.05). Conclusion: OPG levels are increased in COPD patients and correlated with FEV1. After larger and longitudinal studies OPG may be used as a biomarker of the lung function in COPD patients.
dc.identifier.endpage436
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84944276743
dc.identifier.scopusqualityN/A
dc.identifier.startpage431
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5154
dc.identifier.volume31
dc.identifier.wosWOS:000363826100035
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorOran, Mustafa
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorGüzel, Savaş
dc.institutionauthorTopçu, Birol
dc.institutionauthorAvcı, Okan
dc.institutionauthorKüçükyalçın, Volkan
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCOPD
dc.subjectOsteoprotegerin
dc.subjectFEV1
dc.subjectbiomarker
dc.subjectSystemic Inflammation
dc.subjectSerum-Levels
dc.subjectCopd
dc.subjectMen
dc.titleOsteoprotegerin Plasma Concentrations Are Correlated with Forced Expiratory Volume At 1 Second (Fev1) in Patients with Chronic Obstructive Pulmonary Disease
dc.typeArticle

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