Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats

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dc.authorscopusid26432848600
dc.authorscopusid55881189500
dc.authorscopusid29067508300
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorscopusid37058172000
dc.authorscopusid26434076100
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorOran, Mustafa
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorTopçu, Birol
dc.contributor.authorÖzen, Oğuz Aslan
dc.contributor.authorAteş, Özkan
dc.date.accessioned2022-05-11T14:07:32Z
dc.date.available2022-05-11T14:07:32Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractThe goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer's disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase in the frontal cortex tissue. The histopathological studies in the brain of rats also supported that ebselen markedly reduced the ICV-STZ-induced histopathological changes and well preserved the normal histological architecture of the frontal cortex tissue. The number of apoptotic neurons was increased in frontal cortex tissue after ICV-STZ administration. Treatment of ebselen markedly reduced the number of degenerating apoptotic neurons. The study demonstrates the effectiveness of ebselen, as a powerful antioxidant, in preventing the oxidative damage and morphological changes caused by ICV-STZ in rats. Thus, ebselen may have a therapeutic value for the treatment of AD.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects Unit, Tekirdag, TurkeyNamik Kemal University [NKUBAP.00.20. AR.11.06]
dc.description.sponsorshipThis study was supported as project NKUBAP.00.20. AR.11.06 by Namik Kemal University Scientific Research Projects Unit, Tekirdag, Turkey.
dc.identifier.doi10.1177/0748233713509429
dc.identifier.endpage740
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue4en_US
dc.identifier.pmid24231787
dc.identifier.scopus2-s2.0-84962467431
dc.identifier.scopusqualityQ3
dc.identifier.startpage730
dc.identifier.urihttps://doi.org/10.1177/0748233713509429
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5136
dc.identifier.volume32
dc.identifier.wosWOS:000373605800015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorOran, Mustafa
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorTopçu, Birol
dc.institutionauthorÖzen, Oğuz Aslan
dc.institutionauthorAteş, Özkan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIntracerebroventricular streptozotocin
dc.subjectebselen
dc.subjectoxidative stress
dc.subjectneuronal damage
dc.subjectneuronal apoptosis
dc.subjectrats
dc.subjectMild Cognitive Impairment
dc.subjectFree-Radical Theory
dc.subjectAlzheimers-Disease
dc.subjectGlutathione-Peroxidase
dc.subjectCerebral-Ischemia
dc.subjectNeurodegenerative Diseases
dc.subjectBrain Cortex
dc.subjectAdult Rats
dc.subjectAntioxidant
dc.subjectMetabolism
dc.titleNeuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats
dc.typeArticle

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