An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome

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dc.authorid0000-0002-3902-4478
dc.authorscopusid56989001600
dc.authorscopusid20433273500
dc.authorscopusid55985329200
dc.authorscopusid55979401400
dc.authorscopusid57194455341
dc.authorscopusid25633859900
dc.authorscopusid56403229100
dc.authorwosidKarabekiroglu, Koray/G-4424-2011
dc.authorwosidLeckman, James/O-2426-2015
dc.contributor.authorYıldırım, Zeynep
dc.contributor.authorKarabekiroğlu, Koray
dc.contributor.authorYıldıran, Alişan
dc.contributor.authorÇeliksoy, Mehmet Halil
dc.contributor.authorArtukoğlu, Bekir
dc.contributor.authorBaykal, Saliha
dc.contributor.authorLeckman, James
dc.date.accessioned2022-05-11T14:37:18Z
dc.date.available2022-05-11T14:37:18Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground:Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by several motor and phonic tics. Aims:In this study, we aimed to compare activated regulatory T cell (Treg) values between patients with TS/chronic tic disorder (CTD) and age- and sex-matched healthy controls (HCs). Materials and method:Patients with TS/CTD and age- and sex-matched HCs were included in the study. The severity of the disease was evaluated using the Yale Global Tic Severity Scale. CD4(+)CD25(+)CD127(low)Tregs from the patient group and the control group were compared using flow cytometry. Results:The study included 48 patients diagnosed with TS/CTD (36 males and 12 females, mean age: 11.58 +/- 2.61) and 24 HCs (18 males and 6 females, mean age: 11.63 +/- 2.60). The TS/CTD group had significantly higher activated regulatory T percentile with respect to the T helper value compared to the HCs (p = 0.010). Lymphocyte count, T lymphocyte count, T lymphocyte percentage, T-helper lymphocyte count, and T-helper lymphocyte percentage were lower in the patient group compared to the control group (p = 0.024, 0.003, 0.007, <0.001, <0.001, respectively). The comparison of three groups (mild, moderate-severe, and HCs) revealed that T lymphocyte number and percentage and the T helper number and percentage were significantly higher in the HC group compared to the moderate-severe group, whereas the activated Treg percentage with respect to the T helper value was significantly higher in the moderate-severe group compared to the HC group (0.002, 0.026, <0.001, <0.001, 0.027, respectively). Conclusion:Our results suggest that Tregs may have a role in the pathogenesis of TS/CTD.
dc.identifier.doi10.1080/08039488.2020.1779808
dc.identifier.endpage24
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue1en_US
dc.identifier.pmid32580599
dc.identifier.scopus2-s2.0-85087435578
dc.identifier.scopusqualityQ2
dc.identifier.startpage18
dc.identifier.urihttps://doi.org/10.1080/08039488.2020.1779808
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8649
dc.identifier.volume75
dc.identifier.wosWOS:000547719000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaykal, Saliha
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNordic Journal of Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTic disorder
dc.subjectregulatory T cells
dc.subjectautoimmune
dc.subjectStreptococcal Infection
dc.subjectAutoimmune-Disease
dc.subjectMaternal History
dc.subjectImmune Tolerance
dc.subjectPrevalence
dc.subjectInflammation
dc.subjectReliability
dc.subjectExpression
dc.subjectFoxp3
dc.subjectScale
dc.titleAn examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome
dc.typeArticle

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