Association of APJ G212A gene polymorphisms with plasma APJ levels and coronary artery disease risk in Turkish population

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dc.authorid0000-0003-4720-1945
dc.authorwosidAKCILAR, Raziye/A-5351-2018
dc.contributor.authorAkçılar, Raziye
dc.contributor.authorYümün, Gündüz
dc.contributor.authorDonbaloğlu, Mehmet Okan
dc.contributor.authorErselcan, Kubilay
dc.contributor.authorBayat, Zeynep
dc.contributor.authorGenç, Osman
dc.date.accessioned2022-05-11T14:12:47Z
dc.date.available2022-05-11T14:12:47Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractApelin and apelin receptor (APJ) are required for normal cardiovascular development. To investigate the relationship between the APJ G212A polymorphisms and plasma APJ levels and the risk of coronary artery disease (CAD), allele and genotype frequencies of the APJ G212A gene were analysed in were analysed in 152 Turkish patients with CAD and 110 controls by the PCR-RFLP method. The frequencies of genotype GG (57.2% vs 18.2%, P = 0.000, OR = 0.21, 95% CI 0.1 to 0.44) and frequencies of allele G (70.1% vs 46.8%, P = 0.000, OR = 2.65, 95% CI 1.84 to 3.83) at APJ G212A gene polymorphisms were significantly increased in CAD compared with controls. Although plasma APJ level of the patients with GG genotype was lower, It was not statistically significant. CAD patients had significantly lower plasma APJ levels as compared with controls (P = 0.018). On the basis of our results, patients with CAD seem to have lower APJ levels and higher APJ-212 GG genotype and G allele. These results suggested that the APJ G212A gene may be associated with risk for CAD and the APJ G212A gene may play a role in CAD in the Turkish population.
dc.description.sponsorshipDumlupinar UniversityDumlupinar University [2014/49]
dc.description.sponsorshipThis study was supported by Dumlupinar University Research Fund (Project No. 2014/49). The authors are greatful to Dumlupinar Research Center (DPU-ILTEM) for using the laboratory and equipments, to Didem Ocak and Arif Soylu for their help in experimental research.
dc.identifier.endpage3798
dc.identifier.issn1936-2625
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84968807222
dc.identifier.scopusqualityN/A
dc.identifier.startpage3793
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5673
dc.identifier.volume9
dc.identifier.wosWOS:000377594100126
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYümün, Gündüz
dc.institutionauthorDonbaloğlu, Mehmet Okan
dc.institutionauthorErselcan, Kubilay
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAPJ G212A gene
dc.subjectcoronary artery disease
dc.subjectpolymorphism
dc.subjectTurkish population
dc.subjectReceptor Gene
dc.subjectApelin
dc.subjectHeart
dc.subjectLigand
dc.titleAssociation of APJ G212A gene polymorphisms with plasma APJ levels and coronary artery disease risk in Turkish population
dc.typeArticle

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