Elevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome

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dc.authorid0000-0003-0810-6195
dc.authorscopusid24075279000
dc.authorscopusid6506061779
dc.authorscopusid23968920100
dc.authorscopusid55022842500
dc.authorscopusid55481926000
dc.authorscopusid57197051921
dc.authorwosidBastu, Ercan/K-5354-2017
dc.contributor.authorÇelik, Cem
dc.contributor.authorAbalı, Remzi
dc.contributor.authorGüzel, Savaş
dc.contributor.authorBastu, Ercan
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2022-05-11T14:10:05Z
dc.date.available2022-05-11T14:10:05Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective This study investigates human cartilage glycoprotein-39 (YKL-40) levels in patients with polycystic ovary syndrome (PCOS) and controls, and tests their relationship with metabolic and hormonal parameters. Design Clinical study carried out in a university hospital in Tekirdag, Turkey. Patients Eighty-five women with PCOS and normal glucose tolerance (NGT) and twenty-five women with PCOS and abnormal glucose tolerance (AGT), diagnosed according to Rotterdam criteria, and fifty-nine healthy women. Measurements YKL-40 levels, fasting hormone levels and metabolic parameters were investigated in all subjects. Results We showed increased YKL-40 levels in women with PCOS compared to controls. (152.57 +/- 3.96 mu g/l vs 98.16 +/- 1.6 mu g/l, P < 0.000). YKL significantly correlated with BMI (r = 0.344; P < 0.000), 2-h glucose (r = 0.193; P = 0.012), HOMA-IR (r = 0.268; P < 0.000) and fasting insulin (r = 0.310; P < 0.000), but not with waist/hip ratio (r = 0.016; P = 0.832) and fasting glucose (r = 0.108; P = 0.832). When ROC curve analysis was used to analyse the suitability of YKL-40 to identify glucose intolerance in women with PCOS, area under curve for YKL-40 was found to be significant (AGT-PCOS: AUC 0.632, P = 0.046). Conclusion Plasma YKL-40 levels increased in patients with PCOS compared to healthy subjects. Moreover, there was a significant difference in YKL-40 levels between AGT-PCOS and NGT-PCOS subjects. Subsequently, we also found that YKL-40 levels above the cut-off point may help the clinician to predict abnormal glucose tolerance in patients with PCOS.
dc.identifier.doi10.1111/j.1365-2265.2012.04437.x
dc.identifier.endpage897
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue6en_US
dc.identifier.pmid22583189
dc.identifier.scopus2-s2.0-84869051945
dc.identifier.scopusqualityQ2
dc.identifier.startpage893
dc.identifier.urihttps://doi.org/10.1111/j.1365-2265.2012.04437.x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5279
dc.identifier.volume77
dc.identifier.wosWOS:000310962800016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Cem
dc.institutionauthorAbalı, Remzi
dc.institutionauthorGüzel, Savaş
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorYılmaz, Murat
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInsulin-Resistance
dc.subjectPlasma Ykl-40
dc.subjectDisease
dc.subjectBiomarker
dc.subjectRisk
dc.titleElevated circulating levels of YKL-40 are a marker of abnormal glucose tolerance in women with polycystic ovary syndrome
dc.typeArticle

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