Factors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study

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dc.authorid0000-0002-1008-9681
dc.authorid0000-0002-0699-8890
dc.authorid0000-0003-1616-2162
dc.authorscopusid56709532900
dc.authorscopusid25225546400
dc.authorscopusid57219378283
dc.authorscopusid8651321300
dc.authorscopusid55659345800
dc.authorscopusid56902398900
dc.authorscopusid55865109300
dc.authorwosidDagli, Ozgur/AAE-8749-2021
dc.authorwosidYılmaz Karadağ, Fatma/ABC-1574-2021
dc.authorwosidsener, alper/F-6427-2011
dc.authorwosidUgurlu, Kenan/AAW-7991-2021
dc.authorwosidIŞIK, MEHMET EMİRHAN/AAF-5652-2021
dc.authorwosidsavaşçı, ümit/AAA-1667-2021
dc.authorwosidTigen, Elif/AAN-5897-2021
dc.contributor.authorKorkmaz, Pınar
dc.contributor.authorKurtaran, Behice
dc.contributor.authorÖzdemir Armağan, Şule
dc.contributor.authorTuran Özden, Hale
dc.contributor.authorKaçar, Fatma
dc.contributor.authorAteş, Selma
dc.contributor.authorCagan Aktaş, Sabahat
dc.contributor.authorErdem, İlknur
dc.date.accessioned2022-05-11T14:37:23Z
dc.date.available2022-05-11T14:37:23Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description7th International Congress of Infectious-Diseases-and-Clinical-Microbiology-Speciality-Society-of-Turkey -- MAY 08-13, 2018 -- Antalya, TURKEY
dc.description.abstractIntroduction: In this study, we aimed to determine the risk factors associated with inadequate empirical antibiotherapy (IEAT) and hospital-related mortality in elderly patients being treated for upper urinary tract infections (UTI). Materials and Methods: This study included individuals aged 65 years and over who were hospitalized after being diagnosed of community-acquired UTI or community-onset healthcare-associated UTI and followed-up in clinics and/or intensive care units (ICU) of 33 hospitals between March and September 2017. Results: A total of 525 patients (48% males; mean age: 76.46 +/- 7.93 years) were included in the study. Overall, 68.2% of the patients were hospitalized through the emergency department and 73.9% of patients were followed-up for pyelonephritis. Gram-negative, Gram-positive, and Gram-negative and positive mix growths were determined in 88%, 9.3%, and 2.7% of urine cultures, respectively. Fifty-six (10.7%) of the patients died. In multivariate analysis, the presence of chronic obstructive pulmonary disease [Odds ratio (OR): 2.278], age 85 years and over (OR: 2.816), admission to the ICU (OR: 14.831), and IEAT (OR: 2.364) were independent factors that significantly affected mortality. The presence of a urinary catheter, being followed-up in the ICU, benign prostate hypertrophy, use of antibiotics other than piperacillin-tazobactam and carbapenem were determined as independent factors that significantly affected IEAT (p<0.05). Conclusion: In our study, we found a direct correlation between IEAT and mortality. Therefore, knowing the most frequent microorganisms and antibiotic susceptibility profiles observed in the UTI of elderly patients may help to decrease the mortality and morbidity associated with these infections.
dc.description.sponsorshipInfect Dis & Clin Microbil Special Soc Turkiye
dc.identifier.doi10.4274/mjima.galenos.2020.2020.5
dc.identifier.issn2147-673X
dc.identifier.scopus2-s2.0-85111565996
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2020.2020.5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8677
dc.identifier.volume9
dc.identifier.wosWOS:000591513500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobials
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrinary tract infection
dc.subjectempirical
dc.subjectantibiotherapy
dc.subjectmortality
dc.subjectRisk-Factors
dc.subjectCommunity
dc.subjectPrevalence
dc.subjectPrognosis
dc.titleFactors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study
dc.typeConference Object

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