EZH2 expression in the skin of developing human fetuses and adults: a comparative study

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dc.authoridkarabag, sevil/0000-0002-8855-3798
dc.authoridzorlu, ozge/0000-0001-5555-130X
dc.contributor.authorZorlu, Ozge
dc.contributor.authorKarabag, Sevil
dc.contributor.authorErdogan, Kivilcim Eren
dc.contributor.authorKussever, Evin
dc.contributor.authorAslan, Ilke Ozer
dc.date.accessioned2024-10-29T17:58:57Z
dc.date.available2024-10-29T17:58:57Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractPurpose: In animals, the appropriate levels of Enhancer of zeste homolog 2 (EZH2), a well-established epigenetic regulator, are essential for the embryonic development of skin and appendages. We aimed to explore the EZH2 expression patterns in the skin of human fetuses and compare them with adults.Materials and Methods: We performed EZH2 immunohistochemical staining in skin samples from the scalp region of 67 fetuses and from the farthest surgical margin of the lip wedge resection, where no lesions were found, of 23 adults. EZH2 scores were evaluated according to the literature.Results: Epidermal (r = - 0.528), dermal (rs = - 0.509), and hair follicle (r = - 0.576) EZH2 scores were inversely correlated with gestational age. Epidermal and hair follicle EZH2 scores were significantly higher in adults compared to fetuses. There were significant and positive correlations between epidermal, dermal, and hair follicle EZH2 scores among fetuses and adults.Conclusion: Lower levels of EZH2 may be necessary for final cutaneous differentiation and maturation before birth. Our findings may have a therapeutic impact on cutaneous disorders with differentiation defects, chronic wounds, and alopecias.
dc.identifier.doi10.17826/cumj.1321745
dc.identifier.endpage1089
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3en_US
dc.identifier.startpage1081
dc.identifier.trdizinid1199216
dc.identifier.urihttps://doi.org/10.17826/cumj.1321745
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1199216
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14572
dc.identifier.volume48
dc.identifier.wosWOS:001117679900047
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFetus
dc.subjectEZH2
dc.subjectskin
dc.subjectepidermis
dc.subjectdermis
dc.subjecthair follicle
dc.titleEZH2 expression in the skin of developing human fetuses and adults: a comparative study
dc.title.alternativeEZH2 expression in the skin of developing human fetuses and adults: a comparative study
dc.typeArticle

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