Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment

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dc.authorid0000-0002-4060-0583
dc.authorid0000-0001-5992-9488
dc.authorscopusid6601976056
dc.authorscopusid6602805712
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.contributor.authorDonma, Mustafa Metin
dc.contributor.authorDonma, Orkide
dc.date.accessioned2022-05-11T14:37:14Z
dc.date.available2022-05-11T14:37:14Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBurn injury is a severe form of trauma associated with pain, metabolic abnormalities, susceptibility to infections, muscle loss, mental and emotional distress. Conventional therapies as well as some recent approaches for the treatment of burned patients are currently in use. Nutritional therapy is also suggested as a supplementary option in major burns. Within this context, hormones involved in the regulation of appetite will have a paramount importance. The aim is to evaluate the interactions among ghrelin, some inflammatory parameters and the burn injury. Asprosin is also involved into this discussion due to its ghrelin-like actions. Aside from the consideration of insulin as well as stress hormones (cortisol, epinephrine, norepinephrine), an orexigenic, anti-inflammatory hormone, ghrelin affecting both metabolic and inflammatory systems is also involved in the protocols designed for burn treatment. Ghrelin's actions exerted by way of growth-hormone secretagogue receptor, neuropeptide Y, agouti-related protein, proopiomelanocortin and gamma amino butyric acid are being investigated. Asprosin, one of the remarkably few hormones identified as appetite stimulator, acts as another orexigenic hormone by using almost the same signalling pathways as those of ghrelin. Interleukin-6 should also be evaluated both as a reliable biomarker of inflammation and also with its inhibitory effects on TNF-alpha within the scope of burn injury. In conclusion, treatment protocols during burn injury may be designed to raise decreased concentrations of ghrelin and to repress increased levels of inflammatory agents such as TNF-alpha. IL-6 may be evaluated from an entirely different aspect. The potential therapeutic use of asprosin may be considered within an integrative approach with a focus on cachexia-anorexia developed in severe burn trauma.
dc.description.sponsorshipIstanbul University Rectorate, Scientific Research Projects Coordination Unit [5129]
dc.description.sponsorshipThis study was supported by Istanbul University Rectorate, Scientific Research Projects Coordination Unit, Project No: 5129.
dc.identifier.doi10.1016/j.mehy.2018.07.008
dc.identifier.endpage168
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid30037606
dc.identifier.scopus2-s2.0-85049728374
dc.identifier.scopusqualityQ2
dc.identifier.startpage163
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2018.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8627
dc.identifier.volume118
dc.identifier.wosWOS:000442189900032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAsprosin
dc.subjectBurn
dc.subjectGhrelin
dc.subjectInterleukin-6
dc.subjectInterleulcin-10
dc.subjectTumor necrosis factor-alpha
dc.subjectTumor-Necrosis-Factor
dc.subjectRandomized Controlled-Trial
dc.subjectSeverely Burned Children
dc.subjectGrowth-Hormone Treatment
dc.subjectInflammatory Cytokines
dc.subjectCombined Radiation
dc.subject5-Year Outcomes
dc.subjectCancer Cachexia
dc.subjectEnergy-Balance
dc.subjectClinical-Trial
dc.titleAsprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment
dc.typeArticle

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