Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension

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dc.authorid0000-0003-2520-6825
dc.authorid0000-0003-3304-4125
dc.authorscopusid6505680586
dc.authorscopusid57218343711
dc.authorscopusid55317577700
dc.authorscopusid16315021800
dc.authorscopusid57202336559
dc.authorscopusid23968920100
dc.authorscopusid57218338039
dc.authorwosidFidan, Cigdem/X-7070-2018
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorDoğan, Burçin
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorFidan, Çiğdem
dc.contributor.authorGüzel, Savaş
dc.contributor.authorÖzkoyuncu, Berna
dc.date.accessioned2022-05-11T14:10:13Z
dc.date.available2022-05-11T14:10:13Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective The pathophysiology of non-dipper hypertension has not been clarified. The relationship between salusins with atherosclerosis and hypertension has gained attention in recent years. The aim of this paper is to investigate whether salusins are associated with circadian blood pressure, left ventricular mass index, and diastolic functions in newly diagnosed hypertensives. Methods The study included 88 newly diagnosed hypertensive individuals. Twenty-four-hour ambulatory blood pressure monitoring and echocardiographic examinations were performed. The patients were assigned to dipper hypertension (n = 41) and non-dipper hypertension (n = 47) groups based on the ambulatory blood pressure monitoring results according to the presence of >= a 10% decrease in nighttime blood pressure values or not. Serum salusin alpha and beta levels were determined by electrochemiluminescence immunological test method. Results Compared to dipper hypertension, non-dipper hypertension group demonstrated lower salusin alpha levels (1818.71 +/- 221.67 vs 1963 +/- 200.75 pg/mL,p= .002), mitral E/A, septal E'/A' and higher salusin beta levels (576.24 +/- 68.15 vs 516.13 +/- 90.7 pg/ml,p= .001) and left ventricular mass index. Multivariate logistic regression analysis revealed salusin-alpha (OR 0.474, 95% CI 0.262 to 0.986,p= .001), salusin-beta (OR 2.550, 95% CI 2.123 to 2.991,p= .018), and left ventricular mass index (OR 2.620, 95% CI 2.124 to 2.860,p= .011) as independent predictors of non-dipper hypertension. As candidate markers to predict non-dipper hypertension, decreased salusin alpha, and increased salusin beta levels may mediate crosstalk between sympathetic and parasympathetic systems and indicate poor cardiovascular prognosis in hypertension.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects CommissionNamik Kemal University [NKUBAP.02.YL.18.161]; NKUBAP
dc.description.sponsorshipThis study was supported by Namik Kemal University Scientific Research Projects Commission with project number NKUBAP.02.YL.18.161''. We would like to thank NKUBAP, for their support.
dc.identifier.doi10.1080/10641963.2020.1797086
dc.identifier.endpage48
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue1en_US
dc.identifier.pmid32723189
dc.identifier.scopus2-s2.0-85088878061
dc.identifier.scopusqualityQ3
dc.identifier.startpage42
dc.identifier.urihttps://doi.org/10.1080/10641963.2020.1797086
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5328
dc.identifier.volume43
dc.identifier.wosWOS:000553370200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorGür, Özcan
dc.institutionauthorGürkan, Selami
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofClinical and Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmbulatory blood pressure monitoring
dc.subjecthypertension
dc.subjectnon-dipping pattern
dc.subjectsalusin
dc.subjectdipper
dc.subjectAmbulatory Blood-Pressure
dc.subjectLeft-Ventricular Hypertrophy
dc.subjectPrognostic Value
dc.subjectDipping Pattern
dc.subjectAtherosclerosis
dc.subjectDisease
dc.titleAssessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension
dc.typeArticle

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