Does patient age affect survival after radical cystectomy?

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dc.authorid0000-0003-3647-0015
dc.authorid0000-0003-0455-9891
dc.authorscopusid21934448600
dc.authorscopusid23052928300
dc.authorscopusid7004014884
dc.authorscopusid6507566915
dc.authorscopusid7005881894
dc.authorscopusid16417344600
dc.authorscopusid11139575200
dc.authorwosidZlotta, Alexandre/K-8285-2015
dc.contributor.authorHorovitz, David
dc.contributor.authorTürker, Polat
dc.contributor.authorBostrom, Peter J.
dc.contributor.authorMirtti, Tuomas
dc.contributor.authorNurmi, Martti
dc.contributor.authorKuk, Cynthia
dc.contributor.authorZlotta, Alexandre R.
dc.date.accessioned2022-05-11T14:36:56Z
dc.date.available2022-05-11T14:36:56Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE To analyse the impact of patient age on survival after radical cystectomy (RC). PATIENTS AND METHODS After ethics review board approval, two databases of patients with bladder cancer (BC) undergoing RC at the University Heath Network, Toronto, Canada (1992-2008) and the University of Turku, Turku, Finland (1986-2005) were retrospectively analysed. A total of 605 patients who underwent this procedure between June 1985 and March 2010 were included. Patients were divided into four age groups: <= 59, 60-69, 70-79 and >= 80 years. Demographic, clinical and pathological data were compared, as well as recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OAS) rates. RESULTS Compared with younger patients (age <= 79 years), elderly patients (age >= 80 years) had higher American Society of Anesthesiologists scores (P < 0.001), a greater number of lymph nodes removed during surgical dissection (P < 0.001), and underwent less adjuvant treatment (P < 0.001). Choice of urinary diversion differed among the groups, with ileal conduit being used for all patients >= 80 years (P < 0.001). No differences were noted between age groups with respect to RFS (P = 0.3), DSS (P = 0.4) or OAS (P = 0.4). CONCLUSION Although RC is an operation with significant morbidity, it is a viable treatment option for carefully selected elderly patients. Senior patients (>= 80 years) should not be denied RC if they are deemed fit to undergo surgery. Senior adults do not suffer from adverse histopathological features as compared with younger patients.
dc.identifier.doi10.1111/j.1464-410X.2012.11180.x
dc.identifier.endpageE493
dc.identifier.issn1464-4096
dc.identifier.issn1464-410X
dc.identifier.issue11Ben_US
dc.identifier.pmid22551360
dc.identifier.scopus2-s2.0-84876421963
dc.identifier.scopusqualityQ1
dc.identifier.startpageE486
dc.identifier.urihttps://doi.org/10.1111/j.1464-410X.2012.11180.x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8493
dc.identifier.volume110
dc.identifier.wosWOS:000315024200010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTürker, Polat
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBju International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbladder cancer
dc.subjectradical cystectomy
dc.subjectage
dc.subjectelderly
dc.subjectBladder-Cancer
dc.subjectElderly-Patients
dc.subjectComorbidity
dc.subjectOlder
dc.subjectCarcinoma
dc.subjectOutcomes
dc.subjectSurgery
dc.subjectTherapy
dc.titleDoes patient age affect survival after radical cystectomy?
dc.typeArticle

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