Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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dc.authorid0000-0002-3535-5704
dc.authorscopusid8531050000
dc.authorscopusid54892706700
dc.authorscopusid7102765266
dc.authorscopusid8514414100
dc.authorscopusid55881189500
dc.authorscopusid56410921500
dc.authorscopusid56577385000
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorAydın, Murat
dc.contributor.authorTülübaş, Feti
dc.contributor.authorOran, Mustafa
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorKaplan, Gizem
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractExacerbations in chronic obstructive pulmonary disease (COPD) reduce quality of life and are associated with a more rapid deterioration of the disease. Growth differentiation factor-15 (GDF-15) is a novel candidate exacerbation biomarker. In this study, we aimed to assess GDF-15 as a biomarker of acute exacerbation of COPD (AE-COPD). Lung function parameters, arterial blood gas analysis, and circulating levels of GDF-15, C-reactive protein (CRP), and fibrinogen were assessed in 29 patients on admission to the hospital for AE-COPD, in 29 age-, gender-, and body mass index (BMI)-matched patients with stable COPD, and 29 matched controls with normal lung function. Patients with AE-COPD had higher circulating concentrations of GDF-15 (p < 0.001), CRP (p < 0.001), and fibrinogen (p < 0.002) compared with patients with stable COPD and healthy controls. GDF-15 levels correlated with systemic inflammatory marker CRP in patients with AE-COPD (r = 0.677, p < 0.001) and with stable COPD (r = 0.417, p = 0.024). Multivariate logistic regression analysis revealed GDF-15 (odds ratio 18.16, 95 % confidence interval (CI) 2.51-134.32; p = 0.005) as an independent predictor of AE-COPD. In receiver operating characteristic analysis, GDF-15 achieved an area under the curve of 0.78 for the identification of AE-COPD. In conclusion, GDF-15 is a novel blood biomarker of AE-COPD that is more sensitive than that of CRP. GDF-15 may offer new insights into the pathogenesis of AE-COPD.
dc.identifier.doi10.1007/s10753-015-0158-5
dc.identifier.endpage1813
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5en_US
dc.identifier.pmid25820390
dc.identifier.scopus2-s2.0-84941167434
dc.identifier.scopusqualityQ2
dc.identifier.startpage1805
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0158-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9212
dc.identifier.volume38
dc.identifier.wosWOS:000360847200008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorAydın, Murat
dc.institutionauthorTülübaş, Feti
dc.institutionauthorOran, Mustafa
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorKaplan, Gizem
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbiomarker
dc.subjectgrowth differentiation factor-15
dc.subjectchronic obstructive pulmonary disease
dc.subjectinflammation
dc.subjectInflammatory Biomarkers
dc.subjectMortality
dc.subjectRisk
dc.subjectCopd
dc.subjectScore
dc.titleGrowth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease
dc.typeArticle

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