Changes in the brain cortex of rabbits on a cholesterol-rich diet following supplementation with a herbal extract of Tribulus terrestris

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dc.authorid0000-0002-8002-5544
dc.authorid0000-0002-1801-2021
dc.authorscopusid12752602200
dc.authorscopusid6507986489
dc.authorscopusid56213993400
dc.authorscopusid12645794600
dc.authorscopusid7004337877
dc.authorscopusid7006161413
dc.authorwosidTanriover, Gamze/A-3196-2012
dc.authorwosidSati, Leyla/C-2489-2016
dc.contributor.authorBerkman, Zafer
dc.contributor.authorTanriover, Gamze
dc.contributor.authorAcar, Goksemin
dc.contributor.authorSati, Leyla
dc.contributor.authorAltuğ, Tuncay
dc.contributor.authorDemir, Ramazan
dc.date.accessioned2022-05-11T14:34:45Z
dc.date.available2022-05-11T14:34:45Z
dc.date.issued2009
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractExtracts of the medicinal herb Tribulus terrestris (TT) are used for treating various diseases. The saponins, a component of TT, play a role in regulating blood pressure and in treatment of hyperlipidemia. The aim of the study was to investigate the immunohistochemical and ultrastructural alterations in the cerebral cortex of experimental rabbits on a cholesterol rich diet treated with TT. The rabbits were divided into three groups and followed for 12 weeks as control group (CG); experimental group I (EG-I), fed with a cholesterol-rich diet; experimental group II (EG-II), treated with an extract of TT (5mg/kg/day) after a cholesterol-rich diet of 4 weeks. In EG-I there were ultrastructural changes, including mitochondrial degeneration, increased lipofuscin pigments, myelin sheath damage with axoplasmic shrinkage and electron dense granules in the neurovascular unit. The number of synapses apparently decreased in both experimental groups. Administration of TT extract in EG-II led to marked ultrastructural alterations in neurons, including decreased mitochondrial degeneration (P<0.001) and extensive oedematous areas in the neurovascular unit. However, in EG-II, lamellar myelin, axonal structures and mitochondria were well protected. These alterations possibly indicate that saponins have an effect on the neurons either directly or by its conversion to steroidal saponins. Therefore, these findings add further evidence supporting the protective claims of TT in cerebral architecture in dietary induced hyperlipidemia.
dc.description.sponsorshipAkdeniz University Research FoundationAkdeniz University
dc.description.sponsorshipThis article was produced by a collaborative project between the departments of Neurosurgery of Haydarpasa State Hospital and Cardiovascular-Cardiology of Kosuyolu State Hospital, Istanbul; Department of Neurology, Faculty of Medicine, Pamukkale University, Denizli and Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, and Department of Experimental Laboratory, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. This study was partly funded by a grant from Akdeniz University Research Foundation. We would like to thank Sibel Ozer, Arife Demirtop and Hakan Er for their excellent technical assistance, and to Sevil Cayli, Bengi Yaymaci, M. Altug Tuncer for their scientific collaboration.
dc.identifier.endpage692
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue6en_US
dc.identifier.pmid19337967
dc.identifier.scopus2-s2.0-67650254930
dc.identifier.scopusqualityQ2
dc.identifier.startpage683
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8083
dc.identifier.volume24
dc.identifier.wosWOS:000264748400003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBerkman, Zafer
dc.language.isoen
dc.publisherF Hernandez
dc.relation.ispartofHistology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTribulus terrestris
dc.subjectCerebral cortex
dc.subjectRabbit
dc.subjectUltrastructure
dc.subjectSaponin
dc.subjectNonsynaptic Mitochondria
dc.subjectLipid-Composition
dc.subjectRat-Brain
dc.subjectDisease
dc.subjectSheep
dc.subjectProtodioscin
dc.subjectMetabolism
dc.subjectEpithelium
dc.subjectPregnancy
dc.subjectVilli
dc.titleChanges in the brain cortex of rabbits on a cholesterol-rich diet following supplementation with a herbal extract of Tribulus terrestris
dc.typeArticle

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