Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network

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dc.authoridgurer, gulcan/0000-0001-8287-2264
dc.authoridYurdakul, Ozan Volkan/0000-0003-4567-8133
dc.authoridCalis, Mustafa/0000-0002-1184-0772
dc.authoridKAPLAN, HUSEYIN/0000-0002-3292-0907
dc.authoridUcar, Ulku/0000-0003-4838-1650
dc.authoridNAS, Kemal/0000-0002-5845-0851
dc.contributor.authorYurdakul, Fatma Gul
dc.contributor.authorBodur, Hatice
dc.contributor.authorCay, Hasan Fatih
dc.contributor.authorUcar, Ulku
dc.contributor.authorKeskin, Yasar
dc.contributor.authorSargin, Betul
dc.contributor.authorGurer, Guelcan
dc.date.accessioned2024-10-29T17:58:17Z
dc.date.available2024-10-29T17:58:17Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe aim of this study was to analyze the pregnancy process, especially the Familial Mediterranean fever (FMF) disease course and attack types during pregnancy, and to examine the relationship between disease-related factors and female infertility in FMF patients. The study, which was planned in a multicenter national network, included 643 female patients. 435 female patients who had regular sexual intercourse were questioned in terms of infertility. Pregnancy and delivery history, FMF disease severity and course during pregnancy were evaluated. The relationship between demographic and clinical findings, disease severity, genetic analysis results and infertility was investigated. 401 patients had at least 1 pregnancy and 34 patients were diagnosed with infertility. 154 patients had an attack during pregnancy. 61.6% of them reported that attacks during pregnancy were similar to those when they were not pregnant. The most common attack symptoms were fever, fatigue and abdominal pain-peritonitis (96%, 87%, and 83%, respectively) in the pregnancy period. The disease-onset age, disease activity score, gene mutation analyses, and regular colchicine use (> 90%) were similar between the fertile and infertile groups, while the frequency of previous appendectomy and alcohol consumption rates were higher in individuals with infertility. Our results indicated no significant change in the frequency and severity of attacks during pregnancy. The low rate of infertility (7.8%) in our patients was noted. It has been suggested that the risk of FMF-related infertility may not be as high as thought in patients who are followed up regularly and received colchicine.
dc.identifier.doi10.1007/s00296-023-05436-w
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.pmid37658927
dc.identifier.scopus2-s2.0-85169311793
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00296-023-05436-w
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14199
dc.identifier.wosWOS:001061769900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInfertility
dc.subjectPregnancy
dc.subjectAmyloidosis
dc.subjectSerositis
dc.subjectColchicine
dc.titleFamilial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network
dc.typeArticle

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