Serum fetuin-A levels are associated with carotid intima-media thickness in patients with normotensive chronic obstructive pulmonary disease

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dc.authorid0000-0002-3535-5704
dc.authorscopusid6505680586
dc.authorscopusid16315021800
dc.authorscopusid8531050000
dc.authorscopusid55881189500
dc.authorscopusid26532378600
dc.authorscopusid37058172000
dc.authorscopusid55810763400
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorOran, Mustafa
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorTopçu, Birol
dc.contributor.authorGuze, Savas
dc.date.accessioned2022-05-11T14:40:08Z
dc.date.available2022-05-11T14:40:08Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: There are contradictory reports about the relationship between fetuin-A and atherosclerotic process. Coronary artery disease is the most important cause of mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate the association of serum fetuin-A level with mean carotid intima-media thickness (cIMT) and ankle-brachial index (ABI) in COPD. Methods: We evaluated the association of serum fetuin-A level, mean cIMT and ABI in normotensive subjects with COPD (n = 65) and with non-COPD (n = 50). Results: Fetuin-A level was significantly lower (63.5 +/- 19.8 ng/mL, 72.9 +/- 16.2 ng/mL, p = 0.035) and C-reactive protein level higher (4 [1-10] vs. 3 [1-12] mg/dL, p = 0.034) in COPD patients than the control group. Compared to controls, fetuin-A level was significantly lower (63.5 +/- 19.8 ng/mL, 72.9 +/- 16.2 ng/mL, p = 0.035) and mean cIMT higher (0.69 [0.50-0.98] vs. 0.62 [0.44-0.98] mm, p = 0.034, respectively) in the COPD group. There was a significant negative correlation between mean cIMT and fetuin-A levels (r = -0.320, p = 0.032). Age (beta +/- SE: 0.002 +/- 0.001, p = 0.008) and fetuin-A (beta +/- SE: -0.002 +/- 0.001, p = 0.035) were decisive for the mean cIMT. Conclusions: There are increased cIMT values, decreased fetuin-A levels, but unchanged ABI values in patients with normotensive COPD. Age and fetuin-A were predictors for cIMT, while fetuin-A was negatively correlated with cIMT.
dc.identifier.doi10.5603/CJ.a2013.0060
dc.identifier.endpage197
dc.identifier.issn1897-5593
dc.identifier.issn1898-018X
dc.identifier.issue2en_US
dc.identifier.pmid23799555
dc.identifier.scopus2-s2.0-84898627542
dc.identifier.scopusqualityQ2
dc.identifier.startpage191
dc.identifier.urihttps://doi.org/10.5603/CJ.a2013.0060
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8876
dc.identifier.volume21
dc.identifier.wosWOS:000334851500013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorOran, Mustafa
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorTopçu, Birol
dc.institutionauthorGuze, Savas
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofCardiology Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarotid intima-media thickness
dc.subjectchronic obstructive pulmonary disease
dc.subjectfetuin-A
dc.subjectAnkle Brachial Index
dc.subjectCardiovascular Events
dc.subjectVascular-Disease
dc.subjectRisk
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectDiagnosis
dc.subjectSeverity
dc.titleSerum fetuin-A levels are associated with carotid intima-media thickness in patients with normotensive chronic obstructive pulmonary disease
dc.typeArticle

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