Purine catabolic enzymes and nitric oxide in patients with iron deficiency anemia

Basit Öğe Kaydı
dc.authorscopusid55881189500
dc.authorscopusid7102765266
dc.authorscopusid36608599700
dc.authorscopusid8514414100
dc.authorscopusid56082620300
dc.authorscopusid55858591400
dc.authorscopusid36866111300
dc.contributor.authorMete, Rafet
dc.contributor.authorAydın, Murat
dc.contributor.authorTülübaş, Feti
dc.contributor.authorOran, Mustafa
dc.contributor.authorTuran, Bünyamin Cüneyt
dc.contributor.authorTopçu, Birol
dc.contributor.authorGürel, Ahmet
dc.contributor.authorAteş, Hamit
dc.date.accessioned2022-05-11T14:14:03Z
dc.date.available2022-05-11T14:14:03Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIntroduction: To clarify the mechanism of oxidative damage,which affects many tissues and organ systems in iron deficiency anemia, comes into prominence in the treatment and avoiding the complications of the disease. In the present study, serum uric acid, ADA, XO, and nitric oxide (NO) levels were measured in patients with iron deficiency anemia and healthy controls in order to ascertain the function of the above parameters in oxidative stress metabolism. Materials and method: A total of 36 patients (27 female and 9 male with a mean age of 31.1 ± 6.9 years) with iron deficiency anemia and 36 healty controls (29 female and 7 male with a mean age of 29.8 ± 7.7 years) were included in the study. The patients blood parameters, serum iron level, total iron binding capacity and ferritin levels were determined by using commercial kits.Serum adenosine deaminase, xanthine oxidase and nitric oxide measurements were performed spectrophotometrically with manual methods. Results: The levels of xanthine oxidase and uric acid in patients with iron deficiency anemia were found to be significantly lower than healthy controls (p=0.01 and 0.003, respectively), while nitric oxide levels were found to be significantly higher (p = 0.003). Adenosine deaminase levels in patients with iron deficiency anemia were significantly lower than in healthy controls, but the difference was not statistically significant. Discussion: It is known that, oxidative stress increases in iron deficiency anemia due to both increased oxidant molecules and the inadequate capacity of the antioxidant enzyme systems. Decreased levels of xanthine oxidase and uric acid and increased nitric oxide in patients with iron deficiency anemia compared to healthy population is considered to be a result of increased oxidative stress.
dc.identifier.endpage283
dc.identifier.issn0393-6384
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84896828364
dc.identifier.scopusqualityN/A
dc.identifier.startpage279
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5762
dc.identifier.volume30
dc.indekslendigikaynakScopus
dc.institutionauthorMete, Rafet
dc.institutionauthorAydın, Murat
dc.institutionauthorTülübaş, Feti
dc.institutionauthorOran, Mustafa
dc.institutionauthorTuran, Bünyamin Cüneyt
dc.institutionauthorTopçu, Birol
dc.institutionauthorGürel, Ahmet
dc.institutionauthorAteş, Hamit
dc.language.isoen
dc.publisherActa Medica Mediterranea
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdenosine deaminase
dc.subjectIron deficiency anemia
dc.subjectNitric oxide
dc.subjectUric acid
dc.subjectXanthine oxidase
dc.subjectadenosine deaminase
dc.subjectferritin
dc.subjectiron
dc.subjectnitric oxide
dc.subjecturic acid
dc.subjectxanthine oxidase
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectferritin blood level
dc.subjecthuman
dc.subjectiron binding capacity
dc.subjectiron blood level
dc.subjectiron deficiency anemia
dc.subjectmale
dc.subjectoxidative stress
dc.subjectspectrophotometry
dc.subjecturic acid blood level
dc.titlePurine catabolic enzymes and nitric oxide in patients with iron deficiency anemia
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5762.pdf
Boyut:
123.66 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu