Effect of bromelain on periodontal destruction and alveolar bone in rats with experimental periodontitis

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dc.authoridSayiner, Serkan/0000-0002-3297-5369
dc.authoridOrhan, Kaan/0000-0001-6768-0176
dc.authoridUstaoglu, Gulbahar/0000-0002-4205-861X
dc.authoridPaksoy, Tugce/0000-0001-6204-7304
dc.contributor.authorPaksoy, Tugce
dc.contributor.authorUstaoglu, Gulbahar
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorUnsal, Revan Birke Koca
dc.contributor.authorSayiner, Serkan
dc.contributor.authorOrhan, Kaan
dc.contributor.authorAyci, Nurdan Bulbul
dc.date.accessioned2024-10-29T17:58:26Z
dc.date.available2024-10-29T17:58:26Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractPurpose: Several substances that have anti-inflammatory, antiproteinase, and anti-infective properties have been evaluated as modulators of the inflammatory response in periodontal disease. However, evidence for the anti-inflammatory and antioxidative activities of bromelain is limited. This study evaluated the impact of systemi-cally administered bromelain on the progression of experimental periodontitis.Methods: Four equal groups of 32 Wistar albino rats were created as follows (n = 8): control, periodontitis + saline, periodontitis + 5 mg/kg/day bromelain, and periodontitis + 10 mg/kg/day bromelain. To quantify the resorption of bone and bone volume/tissue volume, bone surface / bone volume, and connectivity, lower jaw-bones were fixed and then scanned using microcomputed tomography (micro CT). Blood samples were taken to measure the macrophage colony-stimulating factor(M-CSF) concentrations, receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor-alpha (TNF-& alpha;), matrix metalloproteinase-8 (MMP-8), interleukin-6(IL-6), glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialde-hyde (MDA). Histopathological assessments were made to examine the tissue. Results: Treatment with bromelain improved the healing of the periodontium by decreasing the number of leukocytes and ligament deterioration in the gingival connective tissue and by supporting reintegration with alveolar bone. Bromelain used in ligature-induced periodontitis reduced alveolar bone (AB) resorption as measured by microCT; reduced inflammatory parameters such as IL-6 and TNF-& alpha;; regulated oxidative-antioxidative processes by increasing GPx and SOD and reducing MDA levels; and regulated AB modeling by decreasing M-CSF, RANKL, and MMP-8 and increasing OPG levels.Conclusion: Bromelain may be an option in periodontal therapy by regulating cytokine levels, improving the healing process, and reducing bone resorption and oxidative stress.
dc.identifier.doi10.1016/j.intimp.2023.110446
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid37290321
dc.identifier.scopus2-s2.0-85161281180
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2023.110446
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14317
dc.identifier.volume121
dc.identifier.wosWOS:001018265600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Immunopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlveolar bone loss
dc.subjectAntioxidant
dc.subjectBromelain
dc.subjectPeriodontal diseases
dc.subjectRats
dc.titleEffect of bromelain on periodontal destruction and alveolar bone in rats with experimental periodontitis
dc.typeArticle

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