Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

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dc.authorscopusid55515412500
dc.authorscopusid26434076100
dc.authorscopusid24436194200
dc.authorscopusid55558318400
dc.authorscopusid36023238400
dc.authorscopusid56926829200
dc.authorscopusid25647609500
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.contributor.authorŞener, Ümit
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktaş, Cevat
dc.contributor.authorUygur, Emine
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorBalkaş, Gülseren
dc.contributor.authorErdoğan, Hasan
dc.date.accessioned2022-05-11T14:07:34Z
dc.date.available2022-05-11T14:07:34Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Adli Tıp Ana Bilim Dalı
dc.description.abstractWe aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10mL/kg dose as intragastric was given to the control group. Sodium arsenite (10mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10mg/kg, intragastric by gavage for fifteen days) and TQ (10mg/kg, intragastric by gavage for 15 days) was given to the arsenic+TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic+TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects UnitNamik Kemal University [NKUBAP.00.20.AR.14.02]
dc.description.sponsorshipThe authors declared no conflicts of interest. This study was supported by Namik Kemal University Scientific Research Projects Unit (Project Number: NKUBAP.00.20.AR.14.02).
dc.identifier.doi10.3109/0886022X.2015.1103601
dc.identifier.endpage123
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid26513487
dc.identifier.scopus2-s2.0-84955654059
dc.identifier.scopusqualityQ2
dc.identifier.startpage117
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1103601
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5144
dc.identifier.volume38
dc.identifier.wosWOS:000368809300019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞener, Ümit
dc.institutionauthorUygur, Ramazan
dc.institutionauthorAktaş, Cevat
dc.institutionauthorUygur, Emine
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorBalkaş, Gülseren
dc.institutionauthorErdoğan, Hasan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArsenic
dc.subjectthymoquinone
dc.subjectkidney
dc.subjectapoptosis
dc.subjectoxidative stress
dc.subjectInduced Nephrotoxicity
dc.subjectLipid-Peroxidation
dc.subjectPossible Mechanism
dc.subjectNigella-Sativa
dc.subjectToxicity
dc.subjectTrioxide
dc.subjectAcid
dc.subjectMice
dc.subjectOil
dc.subjectCisplatin
dc.titleProtective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney
dc.typeArticle

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