Disease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: Cross-sectional data from the psoriatic arthritis-international database

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dc.authorscopusid56584131900
dc.authorscopusid22633521000
dc.authorscopusid15763430600
dc.authorscopusid55777347400
dc.authorscopusid55542843700
dc.authorscopusid11539698800
dc.authorscopusid56002299500
dc.contributor.authorBilgin, E.
dc.contributor.authorAydın, S.Z.
dc.contributor.authorTinazzi, I.
dc.contributor.authorBayındır, Ö.
dc.contributor.authorKimyon, G.
dc.contributor.authorÖzişler, C.
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorMercan, Rıdvan
dc.date.accessioned2023-04-20T08:04:16Z
dc.date.available2023-04-20T08:04:16Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective To explore the impact of early versus late-onset psoriasis (PsO) on the disease characteristics of psoriatic arthritis (PsA) in a large-multicentre cohort. Methods The data from a multicentre psoriatic arthritis database was analysed. Patients were grouped according to age at psoriasis onset (early onset; <40 years of age, late-onset; >40 years of age) and disease characteristics of the groups were compared by adjusting for BMI and PsA duration, where necessary. Results At the time of analyses, 1634 patients were recruited [62.8% females; early onset 1108 (67.8%); late-onset, 526 (32.2%)]. The late-onset group was more over-weight [66.8% vs. 86.8%, p<0.001; adjusted for age - aOR 1.55 (1.11-2.20; 95% CI)]. The early onset group had more scalp psoriasis at onset (56.7% vs. 43.0%, p<0.001), whereas extremity lesions were more common in the late-onset group (63.8% vs. 74.2%, p<0.001). Axial disease in males and psoriatic disease family history in females were significantly higher in the early onset group [38.0% vs. 25.4%; p=0.005; adjusted for PsA duration - aOR 1.76 (1.19–2.62; 95% CI) / 39.5% vs. 30.1%; p=0.003; OR 1.51 (1.15–1.99; 95% CI), respectively]. Psoriatic disease activity parameters, patient-physician reported outcomes and HAQ-DI scores were similar in both groups. Conclusion Clinical features of PsA may be affected by the age at onset of PsO. Different genetic backgrounds in early and late-onset PsO may be driving the differences in psoriasis and PsA phenotypes. © Copyright CliniCal and ExpErimEntal rhEumatology 2021.
dc.description.sponsorshipUnion Chimique Belge, UCB
dc.description.sponsorshipCompeting interests: D. Solmaz received funding from Union Chimique Belge (UCB) for an axial fellowship. S. Bakirci received funding from the Turkish Rheumatology Association (TRD). The other co-authors have declared no competing interests.
dc.identifier.endpage536
dc.identifier.issn0392-856X
dc.identifier.issue3en_US
dc.identifier.pmid32662407
dc.identifier.scopus2-s2.0-85106479421
dc.identifier.scopusqualityQ2
dc.identifier.startpage532
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11062
dc.identifier.volume39
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherClinical and Experimental Rheumatology S.A.S.
dc.relation.ispartofClinical and Experimental Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEarly
dc.subjectLate-onset
dc.subjectPsoriasis
dc.subjectPsoriatic arthritis
dc.subjectadult
dc.subjectArticle
dc.subjectbody mass
dc.subjectcohort analysis
dc.subjectdata analysis
dc.subjectdata base
dc.subjectdisease activity
dc.subjectdisease duration
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthuman
dc.subjectlate onset disorder
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectpatient-reported outcome
dc.subjectpriority journal
dc.subjectpsoriasis
dc.subjectpsoriatic arthritis
dc.subjectscalp psoriasis
dc.subjectscoring system
dc.subjectcross-sectional study
dc.subjectpsoriasis
dc.subjectpsoriatic arthritis
dc.subjectAdult
dc.subjectArthritis, Psoriatic
dc.subjectCohort Studies
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPatient Reported Outcome Measures
dc.subjectPsoriasis
dc.titleDisease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: Cross-sectional data from the psoriatic arthritis-international database
dc.typeArticle

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