Relationship between plasma chemerin levels and disease severity in COPD patients

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dc.authorid0000-0001-7213-9624
dc.authorid0000-0002-3535-5704
dc.authorid0000-0001-7213-9624
dc.authorscopusid56291092000
dc.authorscopusid42661653300
dc.authorscopusid56290776600
dc.authorscopusid23968920100
dc.authorscopusid8531050000
dc.authorscopusid55481926000
dc.authorwosidBOYUK, BANU/ABA-7026-2021
dc.authorwosiderman, hande/AAP-6507-2021
dc.authorwosiderman, hande/AAZ-7697-2021
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorBoyuk, Banu
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorAtalay, Hande
dc.contributor.authorGüzel, Savaş
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorKüçükyalçın, Volkan
dc.date.accessioned2022-05-11T14:10:03Z
dc.date.available2022-05-11T14:10:03Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground and AimsChronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD. MethodsForty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects. ResultsSerum chemerin levels were significantly elevated in the COPD patients (6.440.52 vs 5.22 +/- 0.59; P<0.001). A Mann-Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P=0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P>0.05). Pearson's correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P<0.05, r=0.382). In the linear regression analysis, chemerin levels were associated with age (=0.321), triglycerides (=0.299) and T. cholesterol (=0.555). ConclusionOur study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD.
dc.identifier.doi10.1111/crj.12164
dc.identifier.endpage474
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue4en_US
dc.identifier.pmid24865134
dc.identifier.scopus2-s2.0-84943358802
dc.identifier.scopusqualityQ3
dc.identifier.startpage468
dc.identifier.urihttps://doi.org/10.1111/crj.12164
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5266
dc.identifier.volume9
dc.identifier.wosWOS:000362588000013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorGüzel, Savaş
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorKüçükyalçın, Volkan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchemerin
dc.subjectcigarette
dc.subjectCOPD
dc.subjectinflammation
dc.subjectObstructive Pulmonary-Disease
dc.subjectSystemic Inflammation
dc.subjectDendritic Cells
dc.subjectReceptor
dc.subjectChemr23
dc.subjectProteases
dc.subjectObesity
dc.subjectLigand
dc.subjectTig2
dc.titleRelationship between plasma chemerin levels and disease severity in COPD patients
dc.typeArticle

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