An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission

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dc.authoridShaikh, Mohmad Farooq/0000-0001-9865-6224
dc.contributor.authorAkyuz, Enes
dc.contributor.authorArulsamy, Alina
dc.contributor.authorAslan, Feyza Sule
dc.contributor.authorSarisozen, Bugra
dc.contributor.authorGuney, Beyzanur
dc.contributor.authorHekimoglu, Abdulhekim
dc.contributor.authorYilmaz, Beyza Nur
dc.date.accessioned2024-10-29T17:58:21Z
dc.date.available2024-10-29T17:58:21Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAlzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of amyloid-beta (A beta) plaques and tau neurofibrillary tangles are the key players responsible for the pathogenesis of the disease. The accumulation of A beta plaques and tau affect the balance in chemical neurotransmitters in the brain. Thus, the current review examined the role of neurotransmitters in the pathogenesis of Alzheimer's disease and discusses the alterations in the neurochemical activity and cross talk with their receptors and transporters. In the presence of A beta plaques and neurofibrillary tangles, changes may occur in the expression of neuronal receptors which in turn triggers excessive release of glutamate into the synaptic cleft contributing to cell death and neuronal damage. The GABAergic system may also be affected by AD pathology in a similar way. In addition, decreased receptors in the cholinergic system and dysfunction in the dopamine neurotransmission of AD pathology may also contribute to the damage to cognitive function. Moreover, the presence of deficiencies in noradrenergic neurons within the locus coeruleus in AD suggests that noradrenergic stimulation could be useful in addressing its pathophysiology. The regulation of melatonin, known for its effectiveness in enhancing cognitive function and preventing A beta accumulation, along with the involvement of the serotonergic system and histaminergic system in cognition and memory, becomes remarkable for promoting neurotransmission in AD. Additionally, nitric oxide and adenosine-based therapeutic approaches play a protective role in AD by preventing neuroinflammation. Overall, neurotransmitter-based therapeutic strategies emerge as pivotal for addressing neurotransmitter homeostasis and neurotransmission in the context of AD. This review discussed the potential for neurotransmitter-based drugs to be effective in slowing and correcting the neurodegenerative processes in AD by targeting the neurochemical imbalance in the brain. Therefore, neurotransmitter-based drugs could serve as a future therapeutic strategy to tackle AD.
dc.description.sponsorshipMonash University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s12035-024-04333-y
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.pmid39012443
dc.identifier.scopus2-s2.0-85198741984
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12035-024-04333-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14254
dc.identifier.wosWOS:001269333400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Neurobiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer's disease
dc.subjectNeurotransmitters
dc.subjectGlutamate
dc.subjectAcetylcholine
dc.subjectAmyloid-beta
dc.subjectNeurodegeneration
dc.titleAn Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission
dc.typeReview Article

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