Pendant isocyanate and epoxide-containing copolymers: synthesis, sequential dual-functionalization with amines, and surface modifications

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dc.authoridCengiz, Nergiz/0000-0003-2049-0847
dc.authoridGevrek, Tugce Nihal/0000-0002-2297-5891
dc.authoridDemirbilek, Nisa/0000-0003-4450-1221
dc.contributor.authorDemirbilek, Nisa
dc.contributor.authorCengiz, Nergiz
dc.contributor.authorGevrek, Tugce N.
dc.date.accessioned2024-10-29T17:58:36Z
dc.date.available2024-10-29T17:58:36Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractPolymers carrying different reactive groups that can be orthogonally functionalized are desirable for the design of multi-functionalizable materials. While several orthogonally functionalizable polymers have been reported, most of the work utilizes handles that are reactive toward different functional groups. However, examples of polymers that are orthogonally reactive toward molecules bearing the same functional group are rare. In this work, we report polymeric materials that can be sequentially functionalized using different amine-bearing molecules. Herein, we synthesized isocyanate and epoxide group containing copolymers, and investigated their sequential functionalization with amine-containing molecules. We show that such copolymers can be first functionalized with a particular amine-bearing molecule at room temperature, using conjugation through the isocyanate group. Thereafter, a different amine-containing molecule can be attached through the epoxy-amine reaction at 65 degrees C. Chemical characterizations of parent and subsequently functionalized copolymers were done by 1H NMR and FTIR spectroscopy techniques, to establish orthogonal functionalization. Additionally, the epoxide side chains were utilized as surface anchoring group after the functionalization of the polymer via isocyanate-amine reaction. This straightforward approach for obtaining orthogonally reactive amine-functionalizable copolymers, and surfaces derived thereof, would be attractive materials for various biomedical applications.
dc.identifier.doi10.1080/10601325.2023.2216719
dc.identifier.endpage514
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85161442037
dc.identifier.scopusqualityQ2
dc.identifier.startpage505
dc.identifier.urihttps://doi.org/10.1080/10601325.2023.2216719
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14408
dc.identifier.volume60
dc.identifier.wosWOS:000999997600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIsocyanate-amine
dc.subjectepoxy-amine
dc.subjectorthogonal functionalization
dc.subjectfunctionalizable polymers
dc.subjectpolymeric coating
dc.titlePendant isocyanate and epoxide-containing copolymers: synthesis, sequential dual-functionalization with amines, and surface modifications
dc.typeArticle

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