No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome

Basit Öğe Kaydı
dc.authorscopusid6506061779
dc.authorscopusid23986422400
dc.authorscopusid6505680586
dc.authorscopusid56499067400
dc.authorscopusid23968920100
dc.authorscopusid41862830000
dc.authorscopusid56375903100
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAbalı, Remzi
dc.contributor.authorTaşdemir, Nicel
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorTaşdemir, Ufuk Göker
dc.contributor.authorGüzel, Savaş
dc.contributor.authorYüksel, Mehmet Aytaç
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2022-05-11T14:07:41Z
dc.date.available2022-05-11T14:07:41Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractTo investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS). Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups. The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 +/- A 2.29 vs. 10.22 +/- A 2.25 pmol/L, P = 0.026). The mean CIMT was higher in PCOS group than control group (0.52 +/- A 0.058 vs. 0.45 +/- A 0.059 mm, P < 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 +/- A 0.022 vs. 0.055 +/- A 0.029, P = 0.017). We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.
dc.identifier.doi10.1007/s00404-014-3499-7
dc.identifier.endpage1080
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue5en_US
dc.identifier.pmid25280574
dc.identifier.scopus2-s2.0-84925481256
dc.identifier.scopusqualityQ2
dc.identifier.startpage1075
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3499-7
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5175
dc.identifier.volume291
dc.identifier.wosWOS:000351467600019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAbalı, Remzi
dc.institutionauthorTaşdemir, Nicel
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüzel, Savaş
dc.institutionauthorYılmaz, Murat
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolycystic
dc.subjectOvary syndrome
dc.subjectOsteoprotegerin
dc.subjectCarotid intima-media thickness
dc.subjectFLOW-mediated dilatation
dc.subjectCardiovascular disease
dc.subjectIntima-Media Thickness
dc.subjectCoronary-Artery-Disease
dc.subjectCardiovascular Risk-Factors
dc.subjectMiddle-Aged Women
dc.subjectInsulin-Resistance
dc.subjectYoung-Women
dc.subjectPostmenopausal Women
dc.subjectReceptor Activator
dc.subjectSyndrome Pcos
dc.subjectIn-Vitro
dc.titleNo relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5175.pdf
Boyut:
207.67 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu