Oncolytic Myxoma virus Increases Autophagy in Multiple Myeloma

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dc.authoridERDAL, BERNA/0000-0003-3375-7926
dc.contributor.authorYesilaltay, Alpay
dc.contributor.authorMuz, Dilek
dc.contributor.authorErdal, Berna
dc.date.accessioned2024-10-29T17:59:39Z
dc.date.available2024-10-29T17:59:39Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: Multiple myeloma, which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level. In this study, we investigated the effects of Myxoma virus (MYXV), an oncolytic virus, on autophagy in myeloma cells. Materials and Methods: We analyzed protein expressions of ATG-5, p62, Beclin-1, LC3B, and the apoptosis marker Bcl-2 as autophagy markers in human U-266 and mouse MOPC-315 myeloma cell lines subjected to different doses of MYXV. In addition, autophagic images of myeloma cells were investigated using transmission electron microscopy (TEM). Results: In the first 24 h, which is the early stage of autophagy, ATG-5 and Beclin-1 expression levels were increased in the U-266 and MOPC315 cell lines in the groups that had received MYXV at a multiplicity of infection of 15. At 48 h, a significant increase was detected in the expression of LC3B, which is a late indicator. Autophagosomes were observed in myeloma cells by TEM. Conclusion: MYXV shows an antimyeloma effect by increasing autophagy in myeloma cells.
dc.identifier.doi10.4274/tjh.galenos.2024.2023.0403
dc.identifier.endpage25
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue1en_US
dc.identifier.pmid38258554
dc.identifier.scopus2-s2.0-85186744818
dc.identifier.scopusqualityQ3
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2024.2023.0403
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14799
dc.identifier.volume41
dc.identifier.wosWOS:001180241300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMyxoma virus
dc.subjectMultiple myeloma
dc.subjectAutophagy
dc.subjectAutophagosome
dc.titleOncolytic Myxoma virus Increases Autophagy in Multiple Myeloma
dc.typeArticle

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