Evaluation of Pre-Transplant Panel Reactive Antibody Levels and Sensitization: A Single-Center Study

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dc.authorid0000-0002-6688-2347
dc.authorid0000-0002-0409-2710
dc.authorid0000-0001-8720-1400
dc.authorscopusid56689661300
dc.authorscopusid55821927100
dc.authorscopusid6506463113
dc.authorscopusid42360894600
dc.authorscopusid55556291400
dc.authorscopusid8624948000
dc.authorscopusid7004140370
dc.authorwosidATA, PINAR/AAC-9967-2020
dc.authorwosidŞahin, Gülizar/AAA-5296-2021
dc.authorwosidSahin, Gulizar/ABI-6358-2020
dc.contributor.authorCan, Ozgur
dc.contributor.authorGökçe, Ali Murat
dc.contributor.authorCanbakan, Mustafa
dc.contributor.authorAta, Pınar
dc.contributor.authorŞahin, Gülizar Manga
dc.contributor.authorTitiz, Mesut İzzet
dc.contributor.authorApaydın, Süheyla
dc.date.accessioned2022-05-11T14:34:58Z
dc.date.available2022-05-11T14:34:58Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: Sensitization is one of the most important barriers against transplantation. Our aim was to evaluate the sensitization status of our patients awaiting cadaveric transplantation and to identify factors causing sensitization. Material/Methods: A total of 140 patients on the cadaveric waiting list during January 2014 were included in this retrospective cross-sectional study. The parametric t-test and the non-parametric chi-square test were used to detect differences between PRA-positive and -negative patients. Multivariate analysis was used to identify factors associated with PRA positivity. One-way analysis of variance was used to compare PRA-negative and -positive results. Results: Anti-HCV positivity (p=0.040), history of transfusion (p=0.041), and mean number of blood product transfused (p=0.047) were significantly related to class 1 PRA positivity. History of transfusion (p=0.038) and mean number of blood product transfused (p=0.044) were related to class 2 PRA positivity. The multivariate analysis indicated that transfusion and more than 5 units of blood product transfused were related to either class 1 or class 2 PRA positivity. No associations were found between PRA positivity and pregnancy, transplantation, age, sex, infection, abortion, cardiovascular disease, diabetes mellitus, hepatitis B, or time spent on dialysis and being on the transplantation waiting list. Conclusions: Anti-HCV positivity and transfusion are risk factors for sensitization. Particular emphasis should be given to sensitization and its prevention to reduce waiting time for transplantation.
dc.identifier.doi10.12659/AOT.899395
dc.identifier.issn1425-9524
dc.identifier.scopus2-s2.0-84992092933
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.12659/AOT.899395
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8155
dc.identifier.volume21
dc.identifier.wosWOS:000395533600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTitiz, Mesut İzzet
dc.language.isoen
dc.publisherInt Scientific Literature, Inc
dc.relation.ispartofAnnals of Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood Transfusion
dc.subjectHepatitis C Antibodies
dc.subjectHLA Antigens
dc.subjectKidney Transplantation
dc.subjectWaiting Lists
dc.subjectKidney Paired Donation
dc.subjectRenal-Transplantation
dc.subjectHepatitis-C
dc.subjectSurvival
dc.subjectDesensitization
dc.titleEvaluation of Pre-Transplant Panel Reactive Antibody Levels and Sensitization: A Single-Center Study
dc.typeArticle

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